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Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1.
Pihán P, Lisbona F, Borgonovo J, Edwards-Jorquera S, Nunes-Hasler P, Castillo K, Kepp O, Urra H, Saarnio S, Vihinen H, Carreras-Sureda A, Forveille S, Sauvat A, De Giorgis D, Pupo A, Rodríguez DA, Quarato G, Sagredo A, Lourido F, Letai A, Latorre R, Kroemer G, Demaurex N, Jokitalo E, Concha ML, Glavic Á, Green DR, Hetz C. Pihán P, et al. Among authors: letai a. Sci Adv. 2021 Nov 12;7(46):eabe5469. doi: 10.1126/sciadv.abe5469. Epub 2021 Nov 12. Sci Adv. 2021. PMID: 34767445 Free PMC article.
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.
Rodriguez DA, Zamorano S, Lisbona F, Rojas-Rivera D, Urra H, Cubillos-Ruiz JR, Armisen R, Henriquez DR, Cheng EH, Letek M, Vaisar T, Irrazabal T, Gonzalez-Billault C, Letai A, Pimentel-Muiños FX, Kroemer G, Hetz C. Rodriguez DA, et al. Among authors: letai a. EMBO J. 2012 May 16;31(10):2322-35. doi: 10.1038/emboj.2012.84. Epub 2012 Apr 17. EMBO J. 2012. PMID: 22510886 Free PMC article.
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.
Rodriguez DA, Zamorano S, Lisbona F, Rojas-Rivera D, Urra H, Cubillos-Ruiz JR, Armisen R, Henriquez DR, Cheng EH, Letek M, Vaisar T, Irrazabal T, Gonzalez-Billault C, Letai A, Pimentel-Muiños FX, Kroemer G, Hetz C. Rodriguez DA, et al. Among authors: letai a. EMBO J. 2021 Sep 15;40(18):e109146. doi: 10.15252/embj.2021109146. EMBO J. 2021. PMID: 34523136 Free PMC article.
Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer.
Dowling CM, Hollinshead KER, Di Grande A, Pritchard J, Zhang H, Dillon ET, Haley K, Papadopoulos E, Mehta AK, Bleach R, Lindner AU, Mooney B, Düssmann H, O'Connor D, Prehn JHM, Wynne K, Hemann M, Bradner JE, Kimmelman AC, Guerriero JL, Cagney G, Wong KK, Letai AG, Chonghaile TN. Dowling CM, et al. Among authors: letai ag. Sci Adv. 2021 Jan 15;7(3):eabc4897. doi: 10.1126/sciadv.abc4897. Print 2021 Jan. Sci Adv. 2021. PMID: 33523897 Free PMC article.
BCL2 suppresses PARP1 function and nonapoptotic cell death.
Dutta C, Day T, Kopp N, van Bodegom D, Davids MS, Ryan J, Bird L, Kommajosyula N, Weigert O, Yoda A, Fung H, Brown JR, Shapiro GI, Letai A, Weinstock DM. Dutta C, et al. Among authors: letai a. Cancer Res. 2012 Aug 15;72(16):4193-203. doi: 10.1158/0008-5472.CAN-11-4204. Epub 2012 Jun 11. Cancer Res. 2012. PMID: 22689920 Free PMC article.
Adding venetoclax to fludarabine/busulfan RIC transplant for high-risk MDS and AML is feasible, safe, and active.
Garcia JS, Kim HT, Murdock HM, Cutler CS, Brock J, Gooptu M, Ho VT, Koreth J, Nikiforow S, Romee R, Shapiro R, Loschi F, Ryan J, Fell G, Karp HQ, Lucas F, Kim AS, Potter D, Mashaka T, Stone RM, DeAngelo DJ, Letai A, Lindsley RC, Soiffer RJ, Antin JH. Garcia JS, et al. Among authors: letai a. Blood Adv. 2021 Dec 28;5(24):5536-5545. doi: 10.1182/bloodadvances.2021005566. Blood Adv. 2021. PMID: 34614506 Free PMC article. Clinical Trial.
Sequential apoptotic and multiplexed proteomic evaluation of single cancer cells.
Lecky E, Mukherji A, German R, Antonellis G, Lin JR, Yorsz M, McQueeney KE, Ryan J, Ng K, Sicinska E, Sorger PK, Letai A, Bhola PD. Lecky E, et al. Among authors: letai a. Sci Adv. 2023 Jun 23;9(25):eadg4128. doi: 10.1126/sciadv.adg4128. Epub 2023 Jun 23. Sci Adv. 2023. PMID: 37352344 Free PMC article.
216 results