Obita T - Search Results

1

Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation.

Jin M, Shiwaku H, Tanaka H, Obita T, Ohuchi S, Yoshioka Y, Jin X, Kondo K, Fujita K, Homma H, Nakajima K, Mizuguchi M, Okazawa H. Jin M, et al. Among authors: obita t. Nat Commun. 2021 Nov 15;12(1):6565. doi: 10.1038/s41467-021-26851-2. Nat Commun. 2021. PMID: 34782623 Free PMC article.

2

Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15 kD.

Mizuguchi M, Obita T, Serita T, Kojima R, Nabeshima Y, Okazawa H. Mizuguchi M, et al. Among authors: obita t. Nat Commun. 2014 Apr 30;5:3822. doi: 10.1038/ncomms4822. Nat Commun. 2014. PMID: 24781215 Free article.

3

Transient α-helices in the disordered RPEL motifs of the serum response factor coactivator MKL1.

Mizuguchi M, Fuju T, Obita T, Ishikawa M, Tsuda M, Tabuchi A. Mizuguchi M, et al. Among authors: obita t. Sci Rep. 2014 Jun 9;4:5224. doi: 10.1038/srep05224. Sci Rep. 2014. PMID: 24909411 Free PMC article.

4

In silico and pharmacological screenings identify novel serine racemase inhibitors.

Mori H, Wada R, Li J, Ishimoto T, Mizuguchi M, Obita T, Gouda H, Hirono S, Toyooka N. Mori H, et al. Among authors: obita t. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3732-5. doi: 10.1016/j.bmcl.2014.07.003. Epub 2014 Jul 5. Bioorg Med Chem Lett. 2014. PMID: 25066953

5

Characterization of the interaction between Trypanosoma brucei Pex5p and its receptor Pex14p.

Watanabe Y, Kawaguchi K, Okuyama N, Sugawara Y, Obita T, Mizuguchi M, Morita M, Imanaka T. Watanabe Y, et al. Among authors: obita t. FEBS Lett. 2016 Jan;590(2):242-50. doi: 10.1002/1873-3468.12044. Epub 2016 Jan 5. FEBS Lett. 2016. PMID: 26762183 Free article.

6

Structural Fine-Tuning of MIT-Interacting Motif 2 (MIM2) and Allosteric Regulation of ESCRT-III by Vps4 in Yeast.

Kojima R, Obita T, Onoue K, Mizuguchi M. Kojima R, et al. Among authors: obita t. J Mol Biol. 2016 Jun 5;428(11):2392-2404. doi: 10.1016/j.jmb.2016.04.007. Epub 2016 Apr 10. J Mol Biol. 2016. PMID: 27075672

7

Allosteric modulation of the binding affinity between PQBP1 and the spliceosomal protein U5-15kD.

Mizuguchi M, Obita T, Kajiyama A, Kozakai Y, Nakai T, Nabeshima Y, Okazawa H. Mizuguchi M, et al. Among authors: obita t. FEBS Lett. 2016 Jul;590(14):2221-31. doi: 10.1002/1873-3468.12256. Epub 2016 Jun 28. FEBS Lett. 2016. PMID: 27314904 Free article.

8

Crystal Structure of Human General Transcription Factor TFIIE at Atomic Resolution.

Miwa K, Kojima R, Obita T, Ohkuma Y, Tamura Y, Mizuguchi M. Miwa K, et al. Among authors: obita t. J Mol Biol. 2016 Oct 23;428(21):4258-4266. doi: 10.1016/j.jmb.2016.09.008. Epub 2016 Sep 15. J Mol Biol. 2016. PMID: 27639436

9

A novel serine racemase inhibitor suppresses neuronal over-activation in vivo.

Mori H, Wada R, Takahara S, Horino Y, Izumi H, Ishimoto T, Yoshida T, Mizuguchi M, Obita T, Gouda H, Hirono S, Toyooka N. Mori H, et al. Among authors: obita t. Bioorg Med Chem. 2017 Jul 15;25(14):3736-3745. doi: 10.1016/j.bmc.2017.05.011. Epub 2017 May 11. Bioorg Med Chem. 2017. PMID: 28533113

10

Stability and crystal structures of His88 mutant human transthyretins.

Yokoyama T, Hanawa Y, Obita T, Mizuguchi M. Yokoyama T, et al. Among authors: obita t. FEBS Lett. 2017 Jul;591(13):1862-1871. doi: 10.1002/1873-3468.12704. Epub 2017 Jun 20. FEBS Lett. 2017. PMID: 28563699 Free article.

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