Shinozawa T - Search Results

1

Human Organoids for Predictive Toxicology Research and Drug Development.

Matsui T, Shinozawa T. Matsui T, et al. Among authors: shinozawa t. Front Genet. 2021 Nov 1;12:767621. doi: 10.3389/fgene.2021.767621. eCollection 2021. Front Genet. 2021. PMID: 34790228 Free PMC article. Review.

2

Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes.

Matsui T, Miyamoto K, Yamanaka K, Okai Y, Kaushik EP, Harada K, Wagoner M, Shinozawa T. Matsui T, et al. Among authors: shinozawa t. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15. Toxicol Appl Pharmacol. 2019. PMID: 31533062

3

High-Throughput Screening to Evaluate Inhibition of Bile Acid Transporters Using Human Hepatocytes Isolated From Chimeric Mice.

Kohara H, Bajaj P, Yamanaka K, Miyawaki A, Harada K, Miyamoto K, Matsui T, Okai Y, Wagoner M, Shinozawa T. Kohara H, et al. Among authors: shinozawa t. Toxicol Sci. 2020 Feb 1;173(2):347-361. doi: 10.1093/toxsci/kfz229. Toxicol Sci. 2020. PMID: 31722436

4

Molecular Profiling of Human Induced Pluripotent Stem Cell-Derived Cells and their Application for Drug Safety Study.

Matsui T, Miyamoto N, Saito F, Shinozawa T. Matsui T, et al. Among authors: shinozawa t. Curr Pharm Biotechnol. 2020;21(9):807-828. doi: 10.2174/1389201021666200422090952. Curr Pharm Biotechnol. 2020. PMID: 32321398 Review.

5

Video-based assessment of drug-induced effects on contractile motion properties using human induced pluripotent stem cell-derived cardiomyocytes.

Okai Y, Matsune K, Yamanaka K, Matsui T, Pfeiffer Kaushik E, Harada K, Kohara H, Miyawaki A, Ozaki H, Wagoner M, Shinozawa T. Okai Y, et al. Among authors: shinozawa t. J Pharmacol Toxicol Methods. 2020 Sep;105:106893. doi: 10.1016/j.vascn.2020.106893. Epub 2020 Jul 1. J Pharmacol Toxicol Methods. 2020. PMID: 32619502

6

Spontaneous recovery from sunitinib-induced disruption of sarcomere in human iPSC-cardiomyocytes and possible involvement of the Hippo pathway.

Matsui T, Shinozawa T. Matsui T, et al. Among authors: shinozawa t. BMC Pharmacol Toxicol. 2021 Oct 6;22(1):55. doi: 10.1186/s40360-021-00527-5. BMC Pharmacol Toxicol. 2021. PMID: 34610839 Free PMC article.

7

Triclocarban induces lipid droplet accumulation and oxidative stress responses by inhibiting mitochondrial fatty acid oxidation in HepaRG cells.

Nakamura H, Matsui T, Shinozawa T. Nakamura H, et al. Among authors: shinozawa t. Toxicol Lett. 2024 May 15;396:11-18. doi: 10.1016/j.toxlet.2024.04.002. Epub 2024 Apr 15. Toxicol Lett. 2024. PMID: 38631510 Free article.

8

Differences in metabolite genotoxicity test results of rat liver S9 microsomes treated with various microsomal enzyme inducers.

Igaki S, Hashimoto K, Matsui T, Shinozawa T. Igaki S, et al. Among authors: shinozawa t. Toxicol Mech Methods. 2025 Jan 2:1-6. doi: 10.1080/15376516.2024.2443543. Online ahead of print. Toxicol Mech Methods. 2025. PMID: 39745070 Free article.

9

Determination of appropriate stage of human-induced pluripotent stem cell-derived cardiomyocytes for drug screening and pharmacological evaluation in vitro.

Shinozawa T, Imahashi K, Sawada H, Furukawa H, Takami K. Shinozawa T, et al. J Biomol Screen. 2012 Oct;17(9):1192-203. doi: 10.1177/1087057112449864. Epub 2012 Jun 15. J Biomol Screen. 2012. PMID: 22706346

10

Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes.

Shinozawa T, Nakamura K, Shoji M, Morita M, Kimura M, Furukawa H, Ueda H, Shiramoto M, Matsuguma K, Kaji Y, Ikushima I, Yono M, Liou SY, Nagai H, Nakanishi A, Yamamoto K, Izumo S. Shinozawa T, et al. Stem Cell Reports. 2017 Feb 14;8(2):226-234. doi: 10.1016/j.stemcr.2016.12.014. Epub 2017 Jan 19. Stem Cell Reports. 2017. PMID: 28111276 Free PMC article.

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