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Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological and pathological disease in a Syrian hamster model of COVID-19.
Esparza TJ, Chen Y, Martin NP, Bielefeldt-Ohmann H, Bowen RA, Tolbert WD, Pazgier M, Brody DL. Esparza TJ, et al. Among authors: pazgier m. bioRxiv [Preprint]. 2021 Nov 12:2021.11.10.468147. doi: 10.1101/2021.11.10.468147. bioRxiv. 2021. Update in: MAbs. 2022 Jan-Dec;14(1):2047144. doi: 10.1080/19420862.2022.2047144 PMID: 34790977 Free PMC article. Updated. Preprint.
Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.
Chen Y, Sun L, Ullah I, Beaudoin-Bussières G, Anand SP, Hederman AP, Tolbert WD, Sherburn R, Nguyen DN, Marchitto L, Ding S, Wu D, Luo Y, Gottumukkala S, Moran S, Kumar P, Piszczek G, Mothes W, Ackerman ME, Finzi A, Uchil PD, Gonzalez FJ, Pazgier M. Chen Y, et al. Among authors: pazgier m. bioRxiv [Preprint]. 2021 Nov 24:2021.11.24.469776. doi: 10.1101/2021.11.24.469776. bioRxiv. 2021. Update in: Sci Adv. 2022 Jul 15;8(28):eabn4188. doi: 10.1126/sciadv.abn4188 PMID: 34845451 Free PMC article. Updated. Preprint.
VE607 Stabilizes SARS-CoV-2 Spike In the "RBD-up" Conformation and Inhibits Viral Entry.
Ding S, Gong SY, Grover J, Mohammadi M, Chen Y, Vézina D, Beaudoin-Bussières G, Verma VT, Goyette G, Richard J, Yang D, Smith AB, Pazgier M, Côté M, Abrams C, Mothes W, Finzi A, Baron C. Ding S, et al. Among authors: pazgier m. bioRxiv [Preprint]. 2022 Feb 22:2022.02.03.479007. doi: 10.1101/2022.02.03.479007. bioRxiv. 2022. Update in: iScience. 2022 Jul 15;25(7):104528. doi: 10.1016/j.isci.2022.104528 PMID: 35233570 Free PMC article. Updated. Preprint.
Piperidine CD4-mimetic compounds expose vulnerable Env epitopes sensitizing HIV-1-infected cells to ADCC.
Ding S, Tolbert WD, Zhu H, Lee D, Higgins T, Zhao X, Nguyen D, Sherburn R, Richard J, Lepage GG, Medjahed H, Mohammadi M, Abrams C, Pazgier M, Smith AB 3rd, Finzi A. Ding S, et al. Among authors: pazgier m. bioRxiv [Preprint]. 2023 Mar 24:2023.03.23.533923. doi: 10.1101/2023.03.23.533923. bioRxiv. 2023. Update in: Viruses. 2023 May 17;15(5):1185. doi: 10.3390/v15051185 PMID: 36993184 Free PMC article. Updated. Preprint.
Plasmatic HIV-1 soluble gp120 is associated with immune dysfunction and inflammation in ART-treated individuals with undetectable viremia.
Benlarbi M, Richard J, Bourassa C, Tolbert WD, Chartrand-Lefebvre C, Gendron-Lepage G, Sylla M, El-Far M, Messier-Peet M, Guertin C, Turcotte I, Fromentin R, Verly MM, Prévost J, Clark A, Mothes W, Kaufmann DE, Maldarelli F, Chomont N, Bégin P, Tremblay C, Baril JG, Trottier B, Trottier S, Duerr R, Pazgier M, Durand M, Finzi A; Canadian HIV; Aging Cohort Study. Benlarbi M, et al. Among authors: pazgier m. medRxiv [Preprint]. 2023 Aug 16:2023.08.15.23294128. doi: 10.1101/2023.08.15.23294128. medRxiv. 2023. Update in: J Infect Dis. 2024 Mar 14;229(3):763-774. doi: 10.1093/infdis/jiad503 PMID: 37645879 Free PMC article. Updated. Preprint.
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics.
Tauzin A, Marchitto L, Bélanger É, Benlarbi M, Beaudoin-Bussières G, Prévost J, Yang D, Chiu TJ, Chen HC, Bourassa C, Medjahed H, Korzeniowski MK, Gottumukkala S, Tolbert WD, Richard J, Smith AB 3rd, Pazgier M, Finzi A. Tauzin A, et al. Among authors: pazgier m. medRxiv [Preprint]. 2024 Jun 4:2024.06.02.24308281. doi: 10.1101/2024.06.02.24308281. medRxiv. 2024. Update in: J Virol. 2024 Oct 22;98(10):e0096024. doi: 10.1128/jvi.00960-24 PMID: 38883797 Free PMC article. Updated. Preprint.
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Marchitto L, Richard J, Prévost J, Tauzin A, Yang D, Chiu T, Chen HC, Díaz-Salinas MA, Nayrac M, Benlarbi M, Beaudoin-Bussières G, Anand SP, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Bourassa C, Tolbert WD, Hahn BH, Munro JB, Pazgier M, Smith AB 3rd, Finzi A. Marchitto L, et al. Among authors: pazgier m. bioRxiv [Preprint]. 2024 Jun 7:2024.06.07.597978. doi: 10.1101/2024.06.07.597978. bioRxiv. 2024. Update in: J Virol. 2024 Oct 22;98(10):e0101624. doi: 10.1128/jvi.01016-24 PMID: 38895270 Free PMC article. Updated. Preprint.
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC.
Richard J, Grunst MW, Niu L, Díaz-Salinas MA, Tolbert WD, Marchitto L, Zhou F, Bourassa C, Yang D, Chiu TJ, Chen HC, Benlarbi M; Guillaume-Beaudoin-Buissières; Gottumukkala S, Li W, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Hendrickson WA, Sodroski J, Lang ZC, Morton AJ, Huang RK, Matthies D, Smith AB 3rd, Mothes W, Munro JB, Pazgier M, Finzi A. Richard J, et al. Among authors: pazgier m. bioRxiv [Preprint]. 2024 Aug 27:2024.08.27.609961. doi: 10.1101/2024.08.27.609961. bioRxiv. 2024. PMID: 39253431 Free PMC article. Preprint.
Impact of temperature on the affinity of SARS-CoV-2 Spike for ACE2.
Prévost J, Richard J, Gasser R, Ding S, Fage C, Anand SP, Adam D, Vergara NG, Tauzin A, Benlarbi M, Gong SY, Goyette G, Privé A, Moreira S, Charest H, Roger M, Mothes W, Pazgier M, Brochiero E, Boivin G, Abrams CF, Schön A, Finzi A. Prévost J, et al. Among authors: pazgier m. bioRxiv [Preprint]. 2021 Jul 9:2021.07.09.451812. doi: 10.1101/2021.07.09.451812. bioRxiv. 2021. Update in: J Biol Chem. 2021 Oct;297(4):101151. doi: 10.1016/j.jbc.2021.101151 PMID: 34268505 Free PMC article. Updated. Preprint.
126 results