Wittrup KD - Search Results

1

Type I interferon activates MHC class I-dressed CD11b⁺ conventional dendritic cells to promote protective anti-tumor CD8⁺ T cell immunity.

Duong E, Fessenden TB, Lutz E, Dinter T, Yim L, Blatt S, Bhutkar A, Wittrup KD, Spranger S. Duong E, et al. Among authors: wittrup kd. Immunity. 2022 Feb 8;55(2):308-323.e9. doi: 10.1016/j.immuni.2021.10.020. Epub 2021 Nov 19. Immunity. 2022. PMID: 34800368 Free PMC article.

2

Activation of tolerogenic dendritic cells in the tumor draining lymph nodes by CD8+ T cells engineered to express CD40 ligand.

Higham EM, Wittrup KD, Chen J. Higham EM, et al. Among authors: wittrup kd. J Immunol. 2010 Apr 1;184(7):3394-400. doi: 10.4049/jimmunol.0903111. Epub 2010 Mar 3. J Immunol. 2010. PMID: 20200275 Free PMC article.

3

Cutting edge: delay and reversal of T cell tolerance by intratumoral injection of antigen-loaded dendritic cells in an autochthonous tumor model.

Higham EM, Shen CH, Wittrup KD, Chen J. Higham EM, et al. Among authors: wittrup kd. J Immunol. 2010 Jun 1;184(11):5954-8. doi: 10.4049/jimmunol.1000265. Epub 2010 Apr 28. J Immunol. 2010. PMID: 20427765 Free PMC article.

4

Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells.

Bak SP, Barnkob MS, Bai A, Higham EM, Wittrup KD, Chen J. Bak SP, et al. Among authors: wittrup kd. J Immunol. 2012 Aug 15;189(4):1708-16. doi: 10.4049/jimmunol.1201271. Epub 2012 Jul 13. J Immunol. 2012. PMID: 22798683 Free PMC article.

5

CD8+ T-cell responses rapidly select for antigen-negative tumor cells in the prostate.

Bak SP, Barnkob MS, Wittrup KD, Chen J. Bak SP, et al. Among authors: wittrup kd. Cancer Immunol Res. 2013 Dec;1(6):393-401. doi: 10.1158/2326-6066.CIR-13-0109. Epub 2013 Sep 20. Cancer Immunol Res. 2013. PMID: 24778132 Free PMC article.

6

Temporally Programmed CD8α⁺ DC Activation Enhances Combination Cancer Immunotherapy.

Tzeng A, Kauke MJ, Zhu EF, Moynihan KD, Opel CF, Yang NJ, Mehta N, Kelly RL, Szeto GL, Overwijk WW, Irvine DJ, Wittrup KD. Tzeng A, et al. Among authors: wittrup kd. Cell Rep. 2016 Dec 6;17(10):2503-2511. doi: 10.1016/j.celrep.2016.11.020. Cell Rep. 2016. PMID: 27926855 Free PMC article.

7

Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy.

Momin N, Mehta NK, Bennett NR, Ma L, Palmeri JR, Chinn MM, Lutz EA, Kang B, Irvine DJ, Spranger S, Wittrup KD. Momin N, et al. Among authors: wittrup kd. Sci Transl Med. 2019 Jun 26;11(498):eaaw2614. doi: 10.1126/scitranslmed.aaw2614. Sci Transl Med. 2019. PMID: 31243150 Free PMC article.

8

Lack of CD8⁺ T cell effector differentiation during priming mediates checkpoint blockade resistance in non-small cell lung cancer.

Horton BL, Morgan DM, Momin N, Zagorulya M, Torres-Mejia E, Bhandarkar V, Wittrup KD, Love JC, Spranger S. Horton BL, et al. Among authors: wittrup kd. Sci Immunol. 2021 Oct 29;6(64):eabi8800. doi: 10.1126/sciimmunol.abi8800. Epub 2021 Oct 29. Sci Immunol. 2021. PMID: 34714687 Free PMC article.

9

Maximizing response to intratumoral immunotherapy in mice by tuning local retention.

Momin N, Palmeri JR, Lutz EA, Jailkhani N, Mak H, Tabet A, Chinn MM, Kang BH, Spanoudaki V, Hynes RO, Wittrup KD. Momin N, et al. Among authors: wittrup kd. Nat Commun. 2022 Jan 10;13(1):109. doi: 10.1038/s41467-021-27390-6. Nat Commun. 2022. PMID: 35013154 Free PMC article.

10

Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity.

Agarwal Y, Milling LE, Chang JYH, Santollani L, Sheen A, Lutz EA, Tabet A, Stinson J, Ni K, Rodrigues KA, Moyer TJ, Melo MB, Irvine DJ, Wittrup KD. Agarwal Y, et al. Among authors: wittrup kd. Nat Biomed Eng. 2022 Feb;6(2):129-143. doi: 10.1038/s41551-021-00831-9. Epub 2022 Jan 10. Nat Biomed Eng. 2022. PMID: 35013574 Free PMC article.

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