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Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
Bagal SK, Gregson C, O' Donovan DH, Pike KG, Bloecher A, Barton P, Borodovsky A, Code E, Fillery SM, Hsu JH, Kawatkar SP, Li C, Longmire D, Nai Y, Nash SC, Pike A, Robinson J, Read JA, Rawlins PB, Shen M, Tang J, Wang P, Woods H, Williamson B. Bagal SK, et al. Among authors: gregson c. J Med Chem. 2021 Dec 9;64(23):17146-17183. doi: 10.1021/acs.jmedchem.1c01161. Epub 2021 Nov 22. J Med Chem. 2021. PMID: 34807608
Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase.
O' Donovan DH, Gregson C, Packer MJ, Greenwood R, Pike KG, Kawatkar S, Bloecher A, Robinson J, Read J, Code E, Hsu JH, Shen M, Woods H, Barton P, Fillery S, Williamson B, Rawlins PB, Bagal SK. O' Donovan DH, et al. Among authors: gregson c. Bioorg Med Chem Lett. 2021 May 1;39:127904. doi: 10.1016/j.bmcl.2021.127904. Epub 2021 Mar 6. Bioorg Med Chem Lett. 2021. PMID: 33684441
Rapid Identification of Novel Allosteric PRC2 Inhibitors.
Read JA, Tart J, Rawlins PB, Gregson C, Jones K, Gao N, Zhu X, Tomlinson R, Code E, Cheung T, Chen H, Kawatkar SP, Bloecher A, Bagal S, O'Donovan DH, Robinson J. Read JA, et al. Among authors: gregson c. ACS Chem Biol. 2019 Oct 18;14(10):2134-2140. doi: 10.1021/acschembio.9b00468. Epub 2019 Sep 23. ACS Chem Biol. 2019. PMID: 31525019
Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance.
Finlay MRV, Barton P, Bickerton S, Bista M, Colclough N, Cross DAE, Evans L, Floc'h N, Gregson C, Guérot CM, Hargreaves D, Kang X, Lenz EM, Li X, Liu Y, Lorthioir O, Martin MJ, McKerrecher D, McWhirter C, O'Neill D, Orme JP, Mosallanejad A, Rahi A, Smith PD, Talbot V, Ward RA, Wrigley G, Wylot M, Xue L, Yao T, Ye Y, Zhao X. Finlay MRV, et al. Among authors: gregson c. J Med Chem. 2021 Sep 23;64(18):13704-13718. doi: 10.1021/acs.jmedchem.1c01055. Epub 2021 Sep 7. J Med Chem. 2021. PMID: 34491761
Methods for measuring body composition in Zambian adolescents living with HIV.
Filteau S, Chisenga M, Namunkonda C, Mukwasi-Kahari C, Kasonka L, Simms V, Gregson CL, Wells JC. Filteau S, et al. Among authors: gregson cl. PLOS Glob Public Health. 2024 Dec 19;4(12):e0003200. doi: 10.1371/journal.pgph.0003200. eCollection 2024. PLOS Glob Public Health. 2024. PMID: 39700199 Free PMC article.
Structured tailored rehabilitation after hip fragility fracture: The 'Stratify' feasibility and pilot randomised controlled trial protocol.
Sheehan KJ, Guerra S, Ayis S, Goubar A, Foster NE, Martin FC, Godfrey E, Cameron ID, Gregson CL, Walsh NE, Ferguson Montague A, Edwards R, Adams J, Jones GD, Gibson J, Sackley C, Whitney J. Sheehan KJ, et al. Among authors: gregson cl. PLoS One. 2024 Dec 17;19(12):e0306870. doi: 10.1371/journal.pone.0306870. eCollection 2024. PLoS One. 2024. PMID: 39689129 Free PMC article. Clinical Trial.
The role of vitamin D metabolism in regulating bone turnover in adolescents with perinatally-acquired HIV in southern Africa: a cross-sectional study in Zimbabwe and Zambia.
Madanhire T, Ward KA, Macdougall A, Mohammed N, Filteau S, Kasonka L, Mabuda HB, Chisenga M, Tang J, Fraser WD, Bandason T, Dzavakwa NV, Simms V, Ferrand RA, Gregson CL. Madanhire T, et al. Among authors: gregson cl. J Bone Miner Res. 2024 Nov 20:zjae190. doi: 10.1093/jbmr/zjae190. Online ahead of print. J Bone Miner Res. 2024. PMID: 39566074
164 results