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Page 1
Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro-N-(2'-methyl-3'-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1'-biphenyl]-4-yl)benzamide. Structure-Activity Relationship and Preclinical Characterization.
Khedkar NR, Irlapatti NR, Dadke D, Kanoje V, Shaikh Z, Karche V, Shinde V, Deshmukh G, Patil A, Jachak S, Phukan S, Kizhakinagath PA, Gholve M, Bhankhede T, Daler J, Nemade HN, Budhe S, Pareek H, Yeshodharan R, Gupta R, Kalia A, Pandey D, Wagh A, Kumar S, Patil V, Modi D, Sharma N, Ahirrao P, Mehta M, Kumar H, Nigade P, Tamane K, Mallurwar S, Kuldharan S, Pawar S, Vishwase G, Bokan S, Singh M, Naik K, Ingawale S, Shankar R, Kamalakannan P, Venugopal S, George SK, Padiya KJ, Nemmani KVS, Gundu J, Bhonde M, Narasimham L, Sindkhedkar M, Shah C, Sinha N, Sharma S, Bakhle D, Kamboj RK, Palle VP. Khedkar NR, et al. Among authors: ahirrao p. J Med Chem. 2021 Dec 9;64(23):17004-17030. doi: 10.1021/acs.jmedchem.1c01403. Epub 2021 Nov 29. J Med Chem. 2021. PMID: 34843241
Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization.
Karche NP, Bhonde M, Sinha N, Jana G, Kukreja G, Kurhade SP, Jagdale AR, Tilekar AR, Hajare AK, Jadhav GR, Gupta NR, Limaye R, Khedkar N, Thube BR, Shaikh JS, Rao Irlapati N, Phukan S, Gole G, Bommakanti A, Khanwalkar H, Pawar Y, Kale R, Kumar R, Gupta R, Praveen Kumar VR, Wahid S, Francis A, Bhat T, Kamble N, Patil V, Nigade PB, Modi D, Pawar S, Naidu S, Volam H, Pagdala V, Mallurwar S, Goyal H, Bora P, Ahirrao P, Singh M, Kamalakannan P, Naik KR, Kumar P, Powar RG, Shankar RB, Bernstein PR, Gundu J, Nemmani K, Narasimham L, George KS, Sharma S, Bakhle D, Kamboj RK, Palle VP. Karche NP, et al. Among authors: ahirrao p. Bioorg Med Chem. 2020 Dec 15;28(24):115819. doi: 10.1016/j.bmc.2020.115819. Epub 2020 Oct 14. Bioorg Med Chem. 2020. PMID: 33120078
Discovery of a Potent and Selective PI3Kδ Inhibitor (S)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4H-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models.
Shukla MR, Patra S, Verma M, Sadasivam G, Jana N, Mahangare SJ, Vidhate P, Lagad D, Tarage A, Cheemala M, Kulkarni C, Bhagwat S, Chaudhari VD, Sayyed M, Pachpute V, Phadtare R, Gole G, Phukan S, Sunkara B, Samant C, Shingare M, Naik A, Trivedi S, Marisetti AK, Reddy M, Gholve M, Mahajan N, Sabde S, Patil V, Modi D, Mehta M, Nigade P, Tamane K, Tota S, Goyal H, Volam H, Pawar S, Ahirrao P, Dinchhana L, Mallurwar S, Akarte A, Bokare A, Kanhere R, Reddy N, Koul S, Dandekar M, Singh M, Bernstein PR, Narasimham L, Bhonde M, Gundu J, Goel R, Kulkarni S, Sharma S, Kamboj RK, Palle VP. Shukla MR, et al. Among authors: ahirrao p. J Med Chem. 2020 Dec 10;63(23):14700-14723. doi: 10.1021/acs.jmedchem.0c01264. Epub 2020 Dec 1. J Med Chem. 2020. PMID: 33297683
Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis.
Kanoje V, Pandey D, Wagh A, Patra S, Kumar Marisetti A, Reddy M, Samant C, Mahajan N, Gholve M, Sabde S, Trivedi S, Bhankhede T, Patil V, Nigade P, Modi D, Mehta M, Ahirrao P, Tota S, Nanda B, Pawar S, Polawar A, Tamane K, Kuldharan S, Vishwase G, Jana N, Mahangare SJ, Vidhate P, Lagad D, Gundu J, Phukan S, Shukla M, Narasimham L, Nemmani KVS, Bhonde M, Sharma S, Kamboj RK, Palle VP. Kanoje V, et al. Among authors: ahirrao p. Eur J Pharmacol. 2022 Jul 15;927:175054. doi: 10.1016/j.ejphar.2022.175054. Epub 2022 May 27. Eur J Pharmacol. 2022. PMID: 35636524
Dual PI3Kδγ inhibition demonstrates potent anticancer effects in diffuse large B-cell lymphoma models: Discovery and preclinical characterization of LL-00084282.
Verma MK, Samant C, Kale R, Patra S, Mahajan N, Gholve MK, Marisetti A, Sunkara B, Naik A, Shingare M, Reddy M, Bokare AM, Akarte A, Koul S, Nigade PB, Patil VB, Modi D, Ahirrao P, Pawar S, Kuldharan S, Dinchhana L, Mehta M, Gundu J, Jana N, Vidhate P, Mahangare SJ, Shukla MR, Goel RN, Bhonde M, Kamboj RK, Palle VP. Verma MK, et al. Among authors: ahirrao p. Biochem Biophys Res Commun. 2022 Dec 31;637:267-275. doi: 10.1016/j.bbrc.2022.11.038. Epub 2022 Nov 15. Biochem Biophys Res Commun. 2022. PMID: 36410276
Evidence-based treatment for melasma: expert opinion and a review.
Shankar K, Godse K, Aurangabadkar S, Lahiri K, Mysore V, Ganjoo A, Vedamurty M, Kohli M, Sharad J, Kadhe G, Ahirrao P, Narayanan V, Motlekar SA. Shankar K, et al. Among authors: ahirrao p. Dermatol Ther (Heidelb). 2014 Dec;4(2):165-86. doi: 10.1007/s13555-014-0064-z. Epub 2014 Oct 1. Dermatol Ther (Heidelb). 2014. PMID: 25269451 Free PMC article.
Efficacy and tolerability of topical fixed combination of nadifloxacin 1% and adapalene 0.1% in the treatment of mild to moderate acne vulgaris in Indian patients: a multicenter, open-labelled, prospective study.
Shah BJ, Sumathy TK, Dhurat RS, Torsekar RG, Viswanath V, Mukhi JI, Kadhe G, Ahirrao P. Shah BJ, et al. Among authors: ahirrao p. Indian J Dermatol. 2014 Jul;59(4):385-9. doi: 10.4103/0019-5154.135492. Indian J Dermatol. 2014. PMID: 25071260 Free PMC article.
12 results