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MLL1 is regulated by KSHV LANA and is important for virus latency.
Tan M, Li S, Juillard F, Chitas R, Custódio TF, Xue H, Szymula A, Sun Q, Liu B, Álvarez ÁL, Chen S, Huang J, Simas JP, McVey CE, Kaye KM. Tan M, et al. Among authors: simas jp. Nucleic Acids Res. 2021 Dec 16;49(22):12895-12911. doi: 10.1093/nar/gkab1094. Nucleic Acids Res. 2021. PMID: 34850113 Free PMC article.
Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency.
Correia B, Cerqueira SA, Beauchemin C, Pires de Miranda M, Li S, Ponnusamy R, Rodrigues L, Schneider TR, Carrondo MA, Kaye KM, Simas JP, McVey CE. Correia B, et al. Among authors: simas jp. PLoS Pathog. 2013;9(10):e1003673. doi: 10.1371/journal.ppat.1003673. Epub 2013 Oct 17. PLoS Pathog. 2013. PMID: 24146618 Free PMC article.
KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.
Ponnusamy R, Petoukhov MV, Correia B, Custodio TF, Juillard F, Tan M, Pires de Miranda M, Carrondo MA, Simas JP, Kaye KM, Svergun DI, McVey CE. Ponnusamy R, et al. Among authors: simas jp. Nucleic Acids Res. 2015 Nov 16;43(20):10039-54. doi: 10.1093/nar/gkv987. Epub 2015 Sep 30. Nucleic Acids Res. 2015. PMID: 26424851 Free PMC article.
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