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Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation.
Selvadurai MV, Moon MJ, Mountford SJ, Ma X, Zheng Z, Jennings IG, Setiabakti NM, Iman RP, Brazilek RJ, Z Abidin NA, Chicanne G, Severin S, Nicholls AJ, Wong CHY, Rinckel JY, Eckly A, Gachet C, Nesbitt WS, Thompson PE, Hamilton JR. Selvadurai MV, et al. Sci Transl Med. 2020 Jul 22;12(553):eaar8430. doi: 10.1126/scitranslmed.aar8430. Sci Transl Med. 2020. PMID: 32718993
Class II Phosphoinositide 3-Kinases as Novel Drug Targets.
Falasca M, Hamilton JR, Selvadurai M, Sundaram K, Adamska A, Thompson PE. Falasca M, et al. J Med Chem. 2017 Jan 12;60(1):47-65. doi: 10.1021/acs.jmedchem.6b00963. Epub 2016 Oct 21. J Med Chem. 2017. PMID: 27644332 Review.