Bostwick JS - Search Results

1

Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure.

Meng W, Pi Z, Brigance R, Rossi KA, Schumacher WA, Bostwick JS, Gargalovic PS, Onorato JM, Luk CE, Generaux CN, Wang T, Wexler RR, Finlay HJ. Meng W, et al. Among authors: bostwick js. J Med Chem. 2021 Dec 23;64(24):18102-18113. doi: 10.1021/acs.jmedchem.1c01504. Epub 2021 Dec 2. J Med Chem. 2021. PMID: 34855405

2

Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa.

Ewing WR, Becker MR, Manetta VE, Davis RS, Pauls HW, Mason H, Choi-Sledeski YM, Green D, Cha D, Spada AP, Cheney DL, Mason JS, Maignan S, Guilloteau JP, Brown K, Colussi D, Bentley R, Bostwick J, Kasiewski CJ, Morgan SR, Leadley RJ, Dunwiddie CT, Perrone MH, Chu V. Ewing WR, et al. Among authors: bostwick j. J Med Chem. 1999 Sep 9;42(18):3557-71. doi: 10.1021/jm990040h. J Med Chem. 1999. PMID: 10479288

3

Is exogenous tissue plasminogen activator necessary for antithrombotic efficacy of an inhibitor of thrombin activatable fibrinolysis inhibitor (TAFI) in rats?

Bird E, Tamura J, Bostwick JS, Steinbacher TE, Stewart A, Liu Y, Baumann J, Feyen J, Tamasi J, Schumacher WA. Bird E, et al. Among authors: bostwick js. Thromb Res. 2007;120(4):549-58. doi: 10.1016/j.thromres.2006.11.010. Epub 2007 Jan 16. Thromb Res. 2007. PMID: 17229457

4

Biomarker optimization to track the antithrombotic and hemostatic effects of clopidogrel in rats.

Schumacher WA, Bostwick JS, Ogletree ML, Stewart AB, Steinbacher TE, Hua J, Price LA, Wong PC, Rehfuss RP. Schumacher WA, et al. Among authors: bostwick js. J Pharmacol Exp Ther. 2007 Jul;322(1):369-77. doi: 10.1124/jpet.106.119156. Epub 2007 Apr 9. J Pharmacol Exp Ther. 2007. PMID: 17420297

5

Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits.

Wong PC, Crain EJ, Watson CA, Jiang X, Hua J, Bostwick JS, Ogletree ML, Schumacher WA, Rehfuss R. Wong PC, et al. Among authors: bostwick js. J Cardiovasc Pharmacol. 2007 May;49(5):316-24. doi: 10.1097/FJC.0b013e31803e8772. J Cardiovasc Pharmacol. 2007. PMID: 17513951

6

Antithrombotic and hemostatic effects of a small molecule factor XIa inhibitor in rats.

Schumacher WA, Seiler SE, Steinbacher TE, Stewart AB, Bostwick JS, Hartl KS, Liu EC, Ogletree ML. Schumacher WA, et al. Among authors: bostwick js. Eur J Pharmacol. 2007 Sep 10;570(1-3):167-74. doi: 10.1016/j.ejphar.2007.05.043. Epub 2007 Jun 5. Eur J Pharmacol. 2007. PMID: 17597608

7

Effect of the direct factor Xa inhibitor apixaban in rat models of thrombosis and hemostasis.

Schumacher WA, Bostwick JS, Stewart AB, Steinbacher TE, Xin B, Wong PC. Schumacher WA, et al. Among authors: bostwick js. J Cardiovasc Pharmacol. 2010 Jun;55(6):609-16. doi: 10.1097/FJC.0b013e3181daded3. J Cardiovasc Pharmacol. 2010. PMID: 20224421

8

Bleeding response induced by anti-thrombotic doses of a phosphoinositide 3-kinase (PI3K)-β inhibitor in mice.

Bird JE, Smith PL, Bostwick JS, Shipkova P, Schumacher WA. Bird JE, et al. Among authors: bostwick js. Thromb Res. 2011 Jun;127(6):560-4. doi: 10.1016/j.thromres.2011.02.007. Epub 2011 Mar 10. Thromb Res. 2011. PMID: 21396684

9

Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.

Chao H, Turdi H, Herpin TF, Roberge JY, Liu Y, Schnur DM, Poss MA, Rehfuss R, Hua J, Wu Q, Price LA, Abell LM, Schumacher WA, Bostwick JS, Steinbacher TE, Stewart AB, Ogletree ML, Huang CS, Chang M, Cacace AM, Arcuri MJ, Celani D, Wexler RR, Lawrence RM. Chao H, et al. Among authors: bostwick js. J Med Chem. 2013 Feb 28;56(4):1704-14. doi: 10.1021/jm301708u. Epub 2013 Feb 18. J Med Chem. 2013. PMID: 23368907

10

Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility.

Wang TC, Qiao JX, Clark CG, Jua J, Price LA, Wu Q, Chang M, Zheng J, Huang CS, Everlof G, Schumacher WA, Wong PC, Seiffert DA, Stewart AB, Bostwick JS, Crain EJ, Watson CA, Rehfuss R, Wexler RR, Lam PY. Wang TC, et al. Among authors: bostwick js. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3239-43. doi: 10.1016/j.bmcl.2013.03.125. Epub 2013 Apr 6. Bioorg Med Chem Lett. 2013. PMID: 23602442

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