Schwabe JWR - Search Results

1

Structure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone α.

Romartinez-Alonso B, Agostini M, Jones H, McLellan J, Sood DE, Tomkinson N, Marelli F, Gentile I, Visser WE, Schoenmakers E, Fairall L, Privalsky M, Moran C, Persani L, Chatterjee K, Schwabe JWR. Romartinez-Alonso B, et al. Among authors: schwabe jwr. Mol Cell Biol. 2022 Feb 17;42(2):e0036321. doi: 10.1128/MCB.00363-21. Epub 2021 Dec 6. Mol Cell Biol. 2022. PMID: 34871063 Free PMC article.

2

The cocrystal structures of two zinc-stabilized DNA-binding domains illustrate different ways of achieving sequence-specific DNA recognition.

Schwabe JW, Fairall L, Chapman L, Finch JT, Dutnall RN, Rhodes D. Schwabe JW, et al. Cold Spring Harb Symp Quant Biol. 1993;58:141-7. doi: 10.1101/sqb.1993.058.01.018. Cold Spring Harb Symp Quant Biol. 1993. PMID: 7956024 No abstract available.

3

The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition.

Fairall L, Schwabe JW, Chapman L, Finch JT, Rhodes D. Fairall L, et al. Nature. 1993 Dec 2;366(6454):483-7. doi: 10.1038/366483a0. Nature. 1993. PMID: 8247159

4

Towards an understanding of protein-DNA recognition.

Rhodes D, Schwabe JW, Chapman L, Fairall L. Rhodes D, et al. Philos Trans R Soc Lond B Biol Sci. 1996 Apr 29;351(1339):501-9. doi: 10.1098/rstb.1996.0048. Philos Trans R Soc Lond B Biol Sci. 1996. PMID: 8735272 Review.

5

Three novel mutations at serine 314 in the thyroid hormone beta receptor differentially impair ligand binding in the syndrome of resistance to thyroid hormone.

Gurnell M, Rajanayagam O, Agostini M, Clifton-Bligh RJ, Wang T, Zelissen PM, van der Horst F, van de Wiel A, Macchia E, Pinchera A, Schwabe JW, Chatterjee VK. Gurnell M, et al. Endocrinology. 1999 Dec;140(12):5901-6. doi: 10.1210/endo.140.12.7203. Endocrinology. 1999. PMID: 10579356

6

Mechanism of corepressor binding and release from nuclear hormone receptors.

Nagy L, Kao HY, Love JD, Li C, Banayo E, Gooch JT, Krishna V, Chatterjee K, Evans RM, Schwabe JW. Nagy L, et al. Genes Dev. 1999 Dec 15;13(24):3209-16. doi: 10.1101/gad.13.24.3209. Genes Dev. 1999. PMID: 10617570 Free PMC article.

7

A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis.

Gurnell M, Wentworth JM, Agostini M, Adams M, Collingwood TN, Provenzano C, Browne PO, Rajanayagam O, Burris TP, Schwabe JW, Lazar MA, Chatterjee VK. Gurnell M, et al. J Biol Chem. 2000 Feb 25;275(8):5754-9. doi: 10.1074/jbc.275.8.5754. J Biol Chem. 2000. PMID: 10681562 Free article.

8

Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma.

Agostini M, Gurnell M, Savage DB, Wood EM, Smith AG, Rajanayagam O, Garnes KT, Levinson SH, Xu HE, Schwabe JW, Willson TM, O'Rahilly S, Chatterjee VK. Agostini M, et al. Endocrinology. 2004 Apr;145(4):1527-38. doi: 10.1210/en.2003-1271. Epub 2003 Dec 4. Endocrinology. 2004. PMID: 14657011

9

Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance.

Agostini M, Schoenmakers E, Mitchell C, Szatmari I, Savage D, Smith A, Rajanayagam O, Semple R, Luan J, Bath L, Zalin A, Labib M, Kumar S, Simpson H, Blom D, Marais D, Schwabe J, Barroso I, Trembath R, Wareham N, Nagy L, Gurnell M, O'Rahilly S, Chatterjee K. Agostini M, et al. Cell Metab. 2006 Oct;4(4):303-11. doi: 10.1016/j.cmet.2006.09.003. Cell Metab. 2006. PMID: 17011503 Free PMC article.

10

Structural basis for the activation of PPARgamma by oxidized fatty acids.

Itoh T, Fairall L, Amin K, Inaba Y, Szanto A, Balint BL, Nagy L, Yamamoto K, Schwabe JW. Itoh T, et al. Nat Struct Mol Biol. 2008 Sep;15(9):924-31. doi: 10.1038/nsmb.1474. Nat Struct Mol Biol. 2008. PMID: 19172745 Free PMC article.

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