Tomkinson N - Search Results

1

Structure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone α.

Romartinez-Alonso B, Agostini M, Jones H, McLellan J, Sood DE, Tomkinson N, Marelli F, Gentile I, Visser WE, Schoenmakers E, Fairall L, Privalsky M, Moran C, Persani L, Chatterjee K, Schwabe JWR. Romartinez-Alonso B, et al. Among authors: tomkinson n. Mol Cell Biol. 2022 Feb 17;42(2):e0036321. doi: 10.1128/MCB.00363-21. Epub 2021 Dec 6. Mol Cell Biol. 2022. PMID: 34871063 Free PMC article.

2

Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments.

Aatkar A, Vuorinen A, Longfield OE, Gilbert K, Peltier-Heap R, Wagner CD, Zappacosta F, Rittinger K, Chung CW, House D, Tomkinson NCO, Bush JT. Aatkar A, et al. ACS Chem Biol. 2023 Sep 15;18(9):1926-1937. doi: 10.1021/acschembio.3c00034. Epub 2023 Apr 21. ACS Chem Biol. 2023. PMID: 37084287 Free PMC article.

3

Synthesis, characterisation and multi-modal intracellular mapping of cisplatin nano-conjugates.

Leventi AA, Braddick HJ, Billimoria K, Wallace GQ, Goenaga-Infante H, Tomkinson NCO, Faulds K, Graham D. Leventi AA, et al. Among authors: tomkinson nco. Chem Commun (Camb). 2023 May 23;59(42):6395-6398. doi: 10.1039/d3cc00925d. Chem Commun (Camb). 2023. PMID: 37157999 Free article.

4

Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry.

Thomas RP, Grant EK, Dickinson ER, Zappacosta F, Edwards LJ, Hann MM, House D, Tomkinson NCO, Bush JT. Thomas RP, et al. Among authors: tomkinson nco. RSC Med Chem. 2023 Feb 22;14(4):671-679. doi: 10.1039/d2md00453d. eCollection 2023 Apr 26. RSC Med Chem. 2023. PMID: 37122547 Free PMC article.

5

Regioselective Three-Component Reaction of Pyridine N-Oxides, Acyl Chlorides, and Cyclic Ethers.

Jones DH, Kay ST, McLellan JA, Kennedy AR, Tomkinson NCO. Jones DH, et al. Org Lett. 2017 Jul 7;19(13):3512-3515. doi: 10.1021/acs.orglett.7b01481. Epub 2017 Jun 16. Org Lett. 2017. PMID: 28621955 Free article.

6

Regioselective Reaction of Heterocyclic N-Oxides, an Acyl Chloride, and Cyclic Thioethers.

Frei P, Jones DH, Kay ST, McLellan JA, Johnston BF, Kennedy AR, Tomkinson NCO. Frei P, et al. J Org Chem. 2018 Feb 2;83(3):1510-1517. doi: 10.1021/acs.joc.7b02457. Epub 2018 Jan 18. J Org Chem. 2018. PMID: 29345136 Free article.

7

Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation.

Salaun C, Takizawa H, Galindo A, Munro KR, McLellan J, Sugimoto I, Okino T, Tomkinson NCO, Chamberlain LH. Salaun C, et al. J Biol Chem. 2022 Oct;298(10):102469. doi: 10.1016/j.jbc.2022.102469. Epub 2022 Sep 8. J Biol Chem. 2022. PMID: 36087837 Free PMC article.

8

Tracking intracellular uptake and localisation of alkyne tagged fatty acids using Raman spectroscopy.

Jamieson LE, Greaves J, McLellan JA, Munro KR, Tomkinson NCO, Chamberlain LH, Faulds K, Graham D. Jamieson LE, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2018 May 15;197:30-36. doi: 10.1016/j.saa.2018.01.064. Epub 2018 Mar 7. Spectrochim Acta A Mol Biomol Spectrosc. 2018. PMID: 29525355 Free PMC article.

9

Readily accessible chiral at nitrogen cage structures.

Rowley JH, Yau SC, Kariuki BM, Kennedy AR, Tomkinson NC. Rowley JH, et al. Org Biomol Chem. 2013 Apr 7;11(13):2198-205. doi: 10.1039/c3ob27458f. Org Biomol Chem. 2013. PMID: 23403456

10

Improving catalyst activity in secondary amine catalysed transformations.

Brazier JB, Gibbs TJ, Rowley JH, Samulis L, Yau SC, Kennedy AR, Platts JA, Tomkinson NC. Brazier JB, et al. Org Biomol Chem. 2015 Jan 7;13(1):133-41. doi: 10.1039/c4ob01916d. Org Biomol Chem. 2015. PMID: 25347784 Free article.

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