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A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer.
Liu Y, Wu Z, Zhou J, Ramadurai DKA, Mortenson KL, Aguilera-Jimenez E, Yan Y, Yang X, Taylor AM, Varley KE, Gertz J, Choi PS, Cherniack AD, Chen X, Bass AJ, Bailey SD, Zhang X. Liu Y, et al. Among authors: chen x. Nat Commun. 2021 Dec 8;12(1):7139. doi: 10.1038/s41467-021-27055-4. Nat Commun. 2021. PMID: 34880227 Free PMC article.
Non-invasive early detection of cancer four years before conventional diagnosis using a blood test.
Chen X, Gole J, Gore A, He Q, Lu M, Min J, Yuan Z, Yang X, Jiang Y, Zhang T, Suo C, Li X, Cheng L, Zhang Z, Niu H, Li Z, Xie Z, Shi H, Zhang X, Fan M, Wang X, Yang Y, Dang J, McConnell C, Zhang J, Wang J, Yu S, Ye W, Gao Y, Zhang K, Liu R, Jin L. Chen X, et al. Nat Commun. 2020 Jul 21;11(1):3475. doi: 10.1038/s41467-020-17316-z. Nat Commun. 2020. PMID: 32694610 Free PMC article.
Single-cell sequencing of multi-region resolves geospatial architecture and therapeutic target of endothelial cells in esophageal squamous cell carcinoma.
Dai J, Xi X, Liu Z, Wu W, Zhu S, Zhang X, Huang Y, Meng J, Yuan L, Suo C, Xue J, Yuan Z, Lv M, Ye W, Jin L, Zhang G, Chen X. Dai J, et al. Among authors: chen x. Clin Transl Med. 2023 Nov;13(11):e1487. doi: 10.1002/ctm2.1487. Clin Transl Med. 2023. PMID: 37987158 Free PMC article. No abstract available.
Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk.
Suo C, Yang Y, Yuan Z, Zhang T, Yang X, Qing T, Gao P, Shi L, Fan M, Cheng H, Lu M, Jin L, Chen X, Ye W. Suo C, et al. Among authors: chen x. J Thorac Oncol. 2019 Apr;14(4):712-725. doi: 10.1016/j.jtho.2018.12.023. Epub 2019 Jan 9. J Thorac Oncol. 2019. PMID: 30639619 Free article.
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