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Page 1
Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor.
Wang X, Allen S, Blake JF, Bowcut V, Briere DM, Calinisan A, Dahlke JR, Fell JB, Fischer JP, Gunn RJ, Hallin J, Laguer J, Lawson JD, Medwid J, Newhouse B, Nguyen P, O'Leary JM, Olson P, Pajk S, Rahbaek L, Rodriguez M, Smith CR, Tang TP, Thomas NC, Vanderpool D, Vigers GP, Christensen JG, Marx MA. Wang X, et al. Among authors: pajk s. J Med Chem. 2022 Feb 24;65(4):3123-3133. doi: 10.1021/acs.jmedchem.1c01688. Epub 2021 Dec 10. J Med Chem. 2022. PMID: 34889605 Free article.
Discovery of Potent and Selective Covalent Inhibitors of HER2WT and HER2YVMA.
Hicken EJ, Brown K, Dwulet NC, Gaudino JJ, Hansen EP, Hartley DP, Kowalski JP, Laird ER, Lazzara NC, Li B, Mou TC, Mutryn MF, Oko L, Pajk S, Pipal RW, Rosen RZ, Shelp R, Singh A, Wang J, Wise CE, Wong C, Wong JY. Hicken EJ, et al. Among authors: pajk s. J Med Chem. 2024 Jun 13;67(11):9759-9771. doi: 10.1021/acs.jmedchem.4c00978. Epub 2024 May 31. J Med Chem. 2024. PMID: 38820338
A multifaceted approach to understanding protein-buffer interactions in biopharmaceuticals.
Lebar B, Orehova M, Japelj B, Šprager E, Podlipec R, Knaflič T, Urbančič I, Knez B, Zidar M, Cerar J, Mravljak J, Žula A, Arčon D, Plavec J, Pajk S. Lebar B, et al. Among authors: pajk s. Eur J Pharm Biopharm. 2025 Jan;206:114582. doi: 10.1016/j.ejpb.2024.114582. Epub 2024 Nov 19. Eur J Pharm Biopharm. 2025. PMID: 39571949 Free article.
Pseudo-irreversible butyrylcholinesterase inhibitors: Structure-activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead.
Meden A, Knez D, Brazzolotto X, Modeste F, Perdih A, Pišlar A, Zorman M, Zorović M, Denic M, Pajk S, Živin M, Nachon F, Gobec S. Meden A, et al. Among authors: pajk s. Eur J Med Chem. 2023 Feb 5;247:115048. doi: 10.1016/j.ejmech.2022.115048. Epub 2022 Dec 24. Eur J Med Chem. 2023. PMID: 36586299
34 results