Thomas A - Search Results

1

High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain.

Dasovich M, Zhuo J, Goodman JA, Thomas A, McPherson RL, Jayabalan AK, Busa VF, Cheng SJ, Murphy BA, Redinger KR, Alhammad YMO, Fehr AR, Tsukamoto T, Slusher BS, Bosch J, Wei H, Leung AKL. Dasovich M, et al. Among authors: thomas a. ACS Chem Biol. 2022 Jan 21;17(1):17-23. doi: 10.1021/acschembio.1c00721. Epub 2021 Dec 14. ACS Chem Biol. 2022. PMID: 34904435

2

N-Acetylated alpha-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin.

Thomas AG, Vornov JJ, Olkowski JL, Merion AT, Slusher BS. Thomas AG, et al. J Pharmacol Exp Ther. 2000 Oct;295(1):16-22. J Pharmacol Exp Ther. 2000. PMID: 10991955

3

Expression and acquisition of the conditioned place preference response to cocaine in rats is blocked by selective inhibitors of the enzyme N-acetylated-alpha-linked-acidic dipeptidase (NAALADASE).

Slusher BS, Thomas A, Paul M, Schad CA, Ashby CR Jr. Slusher BS, et al. Among authors: thomas a. Synapse. 2001 Jul;41(1):22-8. doi: 10.1002/syn.1056. Synapse. 2001. PMID: 11354010

4

Neuroprotection afforded by NAAG and NAALADase inhibition requires glial cells and metabotropic glutamate receptor activation.

Thomas AG, Olkowski JL, Slusher BS. Thomas AG, et al. Eur J Pharmacol. 2001 Aug 24;426(1-2):35-8. doi: 10.1016/s0014-2999(01)01198-0. Eur J Pharmacol. 2001. PMID: 11525768

5

Glutamate carboxypeptidase II inhibition as a novel therapeutic target.

Rojas C, Thomas AG, Majer P, Tsukamoto T, Lu XM, Vornov JJ, Wozniak KM, Slusher BS. Rojas C, et al. Among authors: thomas ag. Adv Exp Med Biol. 2003;524:205-13. doi: 10.1007/0-306-47920-6_25. Adv Exp Med Biol. 2003. PMID: 12675241 Review. No abstract available.

6

Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II.

Stoermer D, Liu Q, Hall MR, Flanary JM, Thomas AG, Rojas C, Slusher BS, Tsukamoto T. Stoermer D, et al. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2097-100. doi: 10.1016/s0960-894x(03)00407-4. Bioorg Med Chem Lett. 2003. PMID: 12798312

7

NAALADase inhibition protects motor neurons against chronic glutamate toxicity.

Thomas AG, Corse AM, Coccia CF, Bilak MM, Rothstein JD, Slusher BS. Thomas AG, et al. Eur J Pharmacol. 2003 Jun 27;471(3):177-84. doi: 10.1016/s0014-2999(03)01832-6. Eur J Pharmacol. 2003. PMID: 12826236

8

Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models.

Ghadge GD, Slusher BS, Bodner A, Canto MD, Wozniak K, Thomas AG, Rojas C, Tsukamoto T, Majer P, Miller RJ, Monti AL, Roos RP. Ghadge GD, et al. Among authors: thomas ag. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9554-9. doi: 10.1073/pnas.1530168100. Epub 2003 Jul 22. Proc Natl Acad Sci U S A. 2003. PMID: 12876198 Free PMC article.

9

Enantiospecificity of glutamate carboxypeptidase II inhibition.

Tsukamoto T, Majer P, Vitharana D, Ni C, Hin B, Lu XC, Thomas AG, Wozniak KM, Calvin DC, Wu Y, Slusher BS, Scarpetti D, Bonneville GW. Tsukamoto T, et al. J Med Chem. 2005 Apr 7;48(7):2319-24. doi: 10.1021/jm049258g. J Med Chem. 2005. PMID: 15801825

10

Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy.

Thomas AG, Wozniak KM, Tsukamoto T, Calvin D, Wu Y, Rojas C, Vornov J, Slusher BS. Thomas AG, et al. Adv Exp Med Biol. 2006;576:327-37; discussion 361-3. doi: 10.1007/0-387-30172-0_24. Adv Exp Med Biol. 2006. PMID: 16802724 Review.

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