Chen X - Search Results

1

Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.

Lu X, Sabbasani VR, Osei-Amponsa V, Evans CN, King JC, Tarasov SG, Dyba M, Das S, Chan KC, Schwieters CD, Choudhari S, Fromont C, Zhao Y, Tran B, Chen X, Matsuo H, Andresson T, Chari R, Swenson RE, Tarasova NI, Walters KJ. Lu X, et al. Among authors: chen x. Nat Commun. 2021 Dec 16;12(1):7318. doi: 10.1038/s41467-021-27570-4. Nat Commun. 2021. PMID: 34916494 Free PMC article.

2

Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin.

Kang Y, Chen X, Lary JW, Cole JL, Walters KJ. Kang Y, et al. Among authors: chen x. J Mol Biol. 2007 May 25;369(1):168-76. doi: 10.1016/j.jmb.2007.03.008. Epub 2007 Mar 12. J Mol Biol. 2007. PMID: 17408689 Free PMC article.

3

Proteasome subunit Rpn13 is a novel ubiquitin receptor.

Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters KJ, Finley D, Dikic I. Husnjak K, et al. Among authors: chen x. Nature. 2008 May 22;453(7194):481-8. doi: 10.1038/nature06926. Nature. 2008. PMID: 18497817 Free PMC article.

4

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction.

Schreiner P, Chen X, Husnjak K, Randles L, Zhang N, Elsasser S, Finley D, Dikic I, Walters KJ, Groll M. Schreiner P, et al. Among authors: chen x. Nature. 2008 May 22;453(7194):548-52. doi: 10.1038/nature06924. Nature. 2008. PMID: 18497827 Free PMC article.

5

Prokaryotic ubiquitin-like protein pup is intrinsically disordered.

Chen X, Solomon WC, Kang Y, Cerda-Maira F, Darwin KH, Walters KJ. Chen X, et al. J Mol Biol. 2009 Sep 11;392(1):208-17. doi: 10.1016/j.jmb.2009.07.018. Epub 2009 Jul 14. J Mol Biol. 2009. PMID: 19607839 Free PMC article.

6

Measuring ubiquitin chain linkage: Rap80 uses a molecular ruler mechanism for ubiquitin linkage specificity.

Walters KJ, Chen X. Walters KJ, et al. Among authors: chen x. EMBO J. 2009 Aug 19;28(16):2307-8. doi: 10.1038/emboj.2009.221. EMBO J. 2009. PMID: 19690555 Free PMC article. No abstract available.

7

Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2.

Chen X, Lee BH, Finley D, Walters KJ. Chen X, et al. Mol Cell. 2010 May 14;38(3):404-15. doi: 10.1016/j.molcel.2010.04.019. Mol Cell. 2010. PMID: 20471946 Free PMC article.

8

Identifying and studying ubiquitin receptors by NMR.

Chen X, Walters KJ. Chen X, et al. Methods Mol Biol. 2012;832:279-303. doi: 10.1007/978-1-61779-474-2_20. Methods Mol Biol. 2012. PMID: 22350893 Free PMC article.

9

A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer.

Anchoori RK, Karanam B, Peng S, Wang JW, Jiang R, Tanno T, Orlowski RZ, Matsui W, Zhao M, Rudek MA, Hung CF, Chen X, Walters KJ, Roden RB. Anchoori RK, et al. Among authors: chen x. Cancer Cell. 2013 Dec 9;24(6):791-805. doi: 10.1016/j.ccr.2013.11.001. Cancer Cell. 2013. PMID: 24332045 Free PMC article.

10

Structural plasticity allows UCH37 to be primed by RPN13 or locked down by INO80G.

Chen X, Walters KJ. Chen X, et al. Mol Cell. 2015 Mar 5;57(5):767-768. doi: 10.1016/j.molcel.2015.02.025. Mol Cell. 2015. PMID: 25747657 Free PMC article.

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