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Docking Protein p130Cas Regulates Acinar to Ductal Metaplasia During Pancreatic Adenocarcinoma Development and Pancreatitis.
Costamagna A, Natalini D, Camacho Leal MDP, Simoni M, Gozzelino L, Cappello P, Novelli F, Ambrogio C, Defilippi P, Turco E, Giovannetti E, Hirsch E, Cabodi S, Martini M. Costamagna A, et al. Among authors: hirsch e. Gastroenterology. 2022 Apr;162(4):1242-1255.e11. doi: 10.1053/j.gastro.2021.12.242. Epub 2021 Dec 17. Gastroenterology. 2022. PMID: 34922945 Free article.
p130Cas mediates the transforming properties of the anaplastic lymphoma kinase.
Ambrogio C, Voena C, Manazza AD, Piva R, Riera L, Barberis L, Costa C, Tarone G, Defilippi P, Hirsch E, Boeri Erba E, Mohammed S, Jensen ON, Palestro G, Inghirami G, Chiarle R. Ambrogio C, et al. Among authors: hirsch e. Blood. 2005 Dec 1;106(12):3907-16. doi: 10.1182/blood-2005-03-1204. Epub 2005 Aug 16. Blood. 2005. PMID: 16105984 Free PMC article.
Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma.
Costa C, Barberis L, Ambrogio C, Manazza AD, Patrucco E, Azzolino O, Neilsen PO, Ciraolo E, Altruda F, Prestwich GD, Chiarle R, Wymann M, Ridley A, Hirsch E. Costa C, et al. Among authors: hirsch e. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14354-9. doi: 10.1073/pnas.0703175104. Epub 2007 Aug 24. Proc Natl Acad Sci U S A. 2007. PMID: 17720808 Free PMC article.
Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.
Ciraolo E, Iezzi M, Marone R, Marengo S, Curcio C, Costa C, Azzolino O, Gonella C, Rubinetto C, Wu H, Dastrù W, Martin EL, Silengo L, Altruda F, Turco E, Lanzetti L, Musiani P, Rückle T, Rommel C, Backer JM, Forni G, Wymann MP, Hirsch E. Ciraolo E, et al. Among authors: hirsch e. Sci Signal. 2008 Sep 9;1(36):ra3. doi: 10.1126/scisignal.1161577. Sci Signal. 2008. PMID: 18780892 Free PMC article.
PI3K keeps the balance between metabolism and cancer.
Braccini L, Ciraolo E, Martini M, Pirali T, Germena G, Rolfo K, Hirsch E. Braccini L, et al. Among authors: hirsch e. Adv Biol Regul. 2012 Sep;52(3):389-405. doi: 10.1016/j.jbior.2012.04.002. Epub 2012 Apr 24. Adv Biol Regul. 2012. PMID: 22884032 Review.
Targeting PI3K in Cancer: Any Good News?
Martini M, Ciraolo E, Gulluni F, Hirsch E. Martini M, et al. Among authors: hirsch e. Front Oncol. 2013 May 8;3:108. doi: 10.3389/fonc.2013.00108. eCollection 2013. Front Oncol. 2013. PMID: 23658859 Free PMC article.
1,573 results