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Alterations of human skin microbiome and expansion of antimicrobial resistance after systemic antibiotics.
Jo JH, Harkins CP, Schwardt NH, Portillo JA; NISC Comparative Sequencing Program; Zimmerman MD, Carter CL, Hossen MA, Peer CJ, Polley EC, Dartois V, Figg WD, Moutsopoulos NM, Segre JA, Kong HH. Jo JH, et al. Among authors: zimmerman md. Sci Transl Med. 2021 Dec 22;13(625):eabd8077. doi: 10.1126/scitranslmed.abd8077. Epub 2021 Dec 22. Sci Transl Med. 2021. PMID: 34936382 Free PMC article. Clinical Trial.
The association between sterilizing activity and drug distribution into tuberculosis lesions.
Prideaux B, Via LE, Zimmerman MD, Eum S, Sarathy J, O'Brien P, Chen C, Kaya F, Weiner DM, Chen PY, Song T, Lee M, Shim TS, Cho JS, Kim W, Cho SN, Olivier KN, Barry CE 3rd, Dartois V. Prideaux B, et al. Among authors: zimmerman md. Nat Med. 2015 Oct;21(10):1223-7. doi: 10.1038/nm.3937. Epub 2015 Sep 7. Nat Med. 2015. PMID: 26343800 Free PMC article.
Tissue Distribution of Doxycycline in Animal Models of Tuberculosis.
Gengenbacher M, Zimmerman MD, Sarathy JP, Kaya F, Wang H, Mina M, Carter C, Hossen MA, Su H, Trujillo C, Ehrt S, Schnappinger D, Dartois V. Gengenbacher M, et al. Among authors: zimmerman md. Antimicrob Agents Chemother. 2020 Apr 21;64(5):e02479-19. doi: 10.1128/AAC.02479-19. Print 2020 Apr 21. Antimicrob Agents Chemother. 2020. PMID: 32041718 Free PMC article.
Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques.
Winchell CG, Mishra BB, Phuah JY, Saqib M, Nelson SJ, Maiello P, Causgrove CM, Ameel CL, Stein B, Borish HJ, White AG, Klein EC, Zimmerman MD, Dartois V, Lin PL, Sassetti CM, Flynn JL. Winchell CG, et al. Among authors: zimmerman md. Front Immunol. 2020 May 12;11:891. doi: 10.3389/fimmu.2020.00891. eCollection 2020. Front Immunol. 2020. PMID: 32477361 Free PMC article.
Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus.
Negatu DA, Beuchel A, Madani A, Alvarez N, Chen C, Aragaw WW, Zimmerman MD, Laleu B, Gengenbacher M, Dartois V, Imming P, Dick T. Negatu DA, et al. Among authors: zimmerman md. Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0067621. doi: 10.1128/AAC.00676-21. Epub 2021 Jul 16. Antimicrob Agents Chemother. 2021. PMID: 34001512 Free PMC article.
Pharmacokinetics and Target Attainment of SQ109 in Plasma and Human-Like Tuberculosis Lesions in Rabbits.
Egbelowo O, Sarathy JP, Gausi K, Zimmerman MD, Wang H, Wijnant GJ, Kaya F, Gengenbacher M, Van N, Degefu Y, Nacy C, Aldridge BB, Carter CL, Denti P, Dartois V. Egbelowo O, et al. Among authors: zimmerman md. Antimicrob Agents Chemother. 2021 Aug 17;65(9):e0002421. doi: 10.1128/AAC.00024-21. Epub 2021 Aug 17. Antimicrob Agents Chemother. 2021. PMID: 34228540 Free PMC article.
Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus.
Ganapathy US, Lan T, Krastel P, Lindman M, Zimmerman MD, Ho H, Sarathy JP, Evans JC, Dartois V, Aldrich CC, Dick T. Ganapathy US, et al. Among authors: zimmerman md. Antimicrob Agents Chemother. 2021 Aug 17;65(9):e0097821. doi: 10.1128/AAC.00978-21. Epub 2021 Aug 17. Antimicrob Agents Chemother. 2021. PMID: 34228543 Free PMC article.
Lesion Penetration and Activity Limit the Utility of Second-Line Injectable Agents in Pulmonary Tuberculosis.
Ernest JP, Sarathy J, Wang N, Kaya F, Zimmerman MD, Strydom N, Wang H, Xie M, Gengenbacher M, Via LE, Barry CE 3rd, Carter CL, Savic RM, Dartois V. Ernest JP, et al. Among authors: zimmerman md. Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0050621. doi: 10.1128/AAC.00506-21. Epub 2021 Jul 12. Antimicrob Agents Chemother. 2021. PMID: 34252307 Free PMC article.
99 results