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Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila.
Gonçalves AV, Margolis SR, Quirino GFS, Mascarenhas DPA, Rauch I, Nichols RD, Ansaldo E, Fontana MF, Vance RE, Zamboni DS. Gonçalves AV, et al. Among authors: rauch i. PLoS Pathog. 2019 Jun 28;15(6):e1007886. doi: 10.1371/journal.ppat.1007886. eCollection 2019 Jun. PLoS Pathog. 2019. PMID: 31251782 Free PMC article.
NAIP-NLRC4-deficient mice are susceptible to shigellosis.
Mitchell PS, Roncaioli JL, Turcotte EA, Goers L, Chavez RA, Lee AY, Lesser CF, Rauch I, Vance RE. Mitchell PS, et al. Among authors: rauch i. Elife. 2020 Oct 19;9:e59022. doi: 10.7554/eLife.59022. Elife. 2020. PMID: 33074100 Free PMC article.
Innate immune sensing by epithelial barriers.
Constant DA, Nice TJ, Rauch I. Constant DA, et al. Among authors: rauch i. Curr Opin Immunol. 2021 Dec;73:1-8. doi: 10.1016/j.coi.2021.07.014. Epub 2021 Aug 13. Curr Opin Immunol. 2021. PMID: 34392232 Free PMC article. Review.
Epithelial Pyroptosis in Host Defense.
Churchill MJ, Mitchell PS, Rauch I. Churchill MJ, et al. Among authors: rauch i. J Mol Biol. 2022 Feb 28;434(4):167278. doi: 10.1016/j.jmb.2021.167278. Epub 2021 Oct 8. J Mol Biol. 2022. PMID: 34627788 Free PMC article. Review.
43 results