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From Model Organisms to Humans, the Opportunity for More Rigor in Methodologic and Statistical Analysis, Design, and Interpretation of Aging and Senescence Research.
Chusyd DE, Austad SN, Brown AW, Chen X, Dickinson SL, Ejima K, Fluharty D, Golzarri-Arroyo L, Holden R, Jamshidi-Naeini Y, Landsittel D, Lartey S, Mannix E, Vorland CJ, Allison DB. Chusyd DE, et al. Among authors: ejima k. J Gerontol A Biol Sci Med Sci. 2022 Nov 21;77(11):2155-2164. doi: 10.1093/gerona/glab382. J Gerontol A Biol Sci Med Sci. 2022. PMID: 34950945 Free PMC article. Review.
Observational research rigour alone does not justify causal inference.
Ejima K, Li P, Smith DL Jr, Nagy TR, Kadish I, van Groen T, Dawson JA, Yang Y, Patki A, Allison DB. Ejima K, et al. Eur J Clin Invest. 2016 Dec;46(12):985-993. doi: 10.1111/eci.12681. Epub 2016 Oct 28. Eur J Clin Invest. 2016. PMID: 27711975 Free PMC article.
Senolytics improve physical function and increase lifespan in old age.
Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL. Xu M, et al. Among authors: ejima k. Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9. Nat Med. 2018. PMID: 29988130 Free PMC article.
Corrigendum to 'Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease' EBioMedicine 47 (2019) 446-456.
Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Allison DB, Dickinson SL, Ejima K, Atkinson EJ, Lenburg M, Zhu Y, Tchkonia T, Kirkland JL. Hickson LJ, et al. Among authors: ejima k. EBioMedicine. 2020 Feb;52:102595. doi: 10.1016/j.ebiom.2019.12.004. Epub 2020 Jan 23. EBioMedicine. 2020. PMID: 31982828 Free PMC article. No abstract available.
222 results