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Measurements of 5,6-Orthoquinone, a Surrogate for the Presumed Active Primaquine Metabolite 5-Hydroxyprimaquine, in the Urine of Cambodian Adults.
Vanachayangkul P, Sea D, Wojnarski M, Sok S, Kodchakorn C, Ta-Aksorn W, Hom S, Ittiverakul M, Kuntawunginn W, Arsanok M, Buathong N, Heng TK, Nareth K, Nou S, Chandara S, Ly S, Oung P, Vesely B, Bennett J, Reichard G, Pybus B, Lanteri C, Saunders D, Fukuda M, Smith P, Dysoley L, Rekol H, Waters NC, Spring M. Vanachayangkul P, et al. Among authors: pybus b. Antimicrob Agents Chemother. 2022 Mar 15;66(3):e0182121. doi: 10.1128/AAC.01821-21. Epub 2022 Jan 3. Antimicrob Agents Chemother. 2022. PMID: 34978892 Free PMC article.
Primaquine failure and cytochrome P-450 2D6 in Plasmodium vivax malaria.
Bennett JW, Pybus BS, Yadava A, Tosh D, Sousa JC, McCarthy WF, Deye G, Melendez V, Ockenhouse CF. Bennett JW, et al. N Engl J Med. 2013 Oct 3;369(14):1381-2. doi: 10.1056/NEJMc1301936. N Engl J Med. 2013. PMID: 24088113 Free article. Clinical Trial. No abstract available.
Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds.
Marcsisin SR, Sousa JC, Reichard GA, Caridha D, Zeng Q, Roncal N, McNulty R, Careagabarja J, Sciotti RJ, Bennett JW, Zottig VE, Deye G, Li Q, Read L, Hickman M, Dhammika Nanayakkara NP, Walker LA, Smith B, Melendez V, Pybus BS. Marcsisin SR, et al. Among authors: pybus bs. Malar J. 2014 Jan 3;13:2. doi: 10.1186/1475-2875-13-2. Malar J. 2014. PMID: 24386891 Free PMC article.
Enantioselective metabolism of primaquine by human CYP2D6.
Fasinu PS, Tekwani BL, Nanayakkara NP, Avula B, Herath HM, Wang YH, Adelli VR, Elsohly MA, Khan SI, Khan IA, Pybus BS, Marcsisin SR, Reichard GA, McChesney JD, Walker LA. Fasinu PS, et al. Among authors: pybus bs. Malar J. 2014 Dec 17;13:507. doi: 10.1186/1475-2875-13-507. Malar J. 2014. PMID: 25518709 Free PMC article.
Differential CYP 2D6 metabolism alters primaquine pharmacokinetics.
Potter BM, Xie LH, Vuong C, Zhang J, Zhang P, Duan D, Luong TL, Bandara Herath HM, Dhammika Nanayakkara NP, Tekwani BL, Walker LA, Nolan CK, Sciotti RJ, Zottig VE, Smith PL, Paris RM, Read LT, Li Q, Pybus BS, Sousa JC, Reichard GA, Marcsisin SR. Potter BM, et al. Antimicrob Agents Chemother. 2015 Apr;59(4):2380-7. doi: 10.1128/AAC.00015-15. Epub 2015 Feb 2. Antimicrob Agents Chemother. 2015. PMID: 25645856 Free PMC article.
Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics.
Vuong C, Xie LH, Potter BM, Zhang J, Zhang P, Duan D, Nolan CK, Sciotti RJ, Zottig VE, Nanayakkara NP, Tekwani BL, Walker LA, Smith PL, Paris RM, Read LT, Li Q, Pybus BS, Sousa JC, Reichard GA, Smith B, Marcsisin SR. Vuong C, et al. Among authors: pybus bs. Antimicrob Agents Chemother. 2015 Jul;59(7):3864-9. doi: 10.1128/AAC.00343-15. Epub 2015 Apr 13. Antimicrob Agents Chemother. 2015. PMID: 25870069 Free PMC article.
41 results