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PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective.
Orozco Morales ML, Rinaldi CA, de Jong E, Lansley SM, Gummer JPA, Olasz B, Nambiar S, Hope DE, Casey TH, Lee YCG, Leslie C, Nealon G, Shackleford DM, Powell AK, Grimaldi M, Balaguer P, Zemek RM, Bosco A, Piggott MJ, Vrielink A, Lake RA, Lesterhuis WJ. Orozco Morales ML, et al. Among authors: zemek rm. iScience. 2021 Dec 4;25(1):103571. doi: 10.1016/j.isci.2021.103571. eCollection 2022 Jan 21. iScience. 2021. PMID: 34984327 Free PMC article.
Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment.
Zemek RM, De Jong E, Chin WL, Schuster IS, Fear VS, Casey TH, Forbes C, Dart SJ, Leslie C, Zaitouny A, Small M, Boon L, Forrest ARR, Muiri DO, Degli-Esposti MA, Millward MJ, Nowak AK, Lassmann T, Bosco A, Lake RA, Lesterhuis WJ. Zemek RM, et al. Sci Transl Med. 2019 Jul 17;11(501):eaav7816. doi: 10.1126/scitranslmed.aav7816. Sci Transl Med. 2019. PMID: 31316010 Free article.
Tumor Infiltrating Effector Memory Antigen-Specific CD8+ T Cells Predict Response to Immune Checkpoint Therapy.
Principe N, Kidman J, Goh S, Tilsed CM, Fisher SA, Fear VS, Forbes CA, Zemek RM, Chopra A, Watson M, Dick IM, Boon L, Holt RA, Lake RA, Nowak AK, Lesterhuis WJ, McDonnell AM, Chee J. Principe N, et al. Among authors: zemek rm. Front Immunol. 2020 Nov 12;11:584423. doi: 10.3389/fimmu.2020.584423. eCollection 2020. Front Immunol. 2020. PMID: 33262762 Free PMC article.
CD4+ T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapy.
Tilsed CM, Principe N, Kidman J, Chin WL, Orozco Morales ML, Zemek RM, Chee J, Islam R, Fear VS, Forbes C, Aston WJ, Jansen M, Chopra A, Lassmann T, Nowak AK, Fisher SA, Lake RA, Lesterhuis WJ. Tilsed CM, et al. Among authors: zemek rm. Cell Rep. 2022 Dec 27;41(13):111874. doi: 10.1016/j.celrep.2022.111874. Cell Rep. 2022. PMID: 36577370 Free article.
19 results