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Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.
Hurdiss DL, El Kazzi P, Bauer L, Papageorgiou N, Ferron FP, Donselaar T, van Vliet ALW, Shamorkina TM, Snijder J, Canard B, Decroly E, Brancale A, Zeev-Ben-Mordehai T, Förster F, van Kuppeveld FJM, Coutard B. Hurdiss DL, et al. Among authors: van vliet alw. Sci Adv. 2022 Jan 7;8(1):eabj7615. doi: 10.1126/sciadv.abj7615. Epub 2022 Jan 5. Sci Adv. 2022. PMID: 34985963 Free PMC article.
Enterovirus D68 receptor requirements unveiled by haploid genetics.
Baggen J, Thibaut HJ, Staring J, Jae LT, Liu Y, Guo H, Slager JJ, de Bruin JW, van Vliet AL, Blomen VA, Overduin P, Sheng J, de Haan CA, de Vries E, Meijer A, Rossmann MG, Brummelkamp TR, van Kuppeveld FJ. Baggen J, et al. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1399-404. doi: 10.1073/pnas.1524498113. Epub 2016 Jan 19. Proc Natl Acad Sci U S A. 2016. PMID: 26787879 Free PMC article.
Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus.
Baggen J, Hurdiss DL, Zocher G, Mistry N, Roberts RW, Slager JJ, Guo H, van Vliet ALW, Wahedi M, Benschop K, Duizer E, de Haan CAM, de Vries E, Casasnovas JM, de Groot RJ, Arnberg N, Stehle T, Ranson NA, Thibaut HJ, van Kuppeveld FJM. Baggen J, et al. Among authors: van vliet alw. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):397-402. doi: 10.1073/pnas.1713284115. Epub 2017 Dec 28. Proc Natl Acad Sci U S A. 2018. PMID: 29284752 Free PMC article.
Molecular basis for the acid-initiated uncoating of human enterovirus D68.
Liu Y, Sheng J, van Vliet ALW, Buda G, van Kuppeveld FJM, Rossmann MG. Liu Y, et al. Among authors: van vliet alw. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12209-E12217. doi: 10.1073/pnas.1803347115. Epub 2018 Dec 10. Proc Natl Acad Sci U S A. 2018. PMID: 30530701 Free PMC article.
Bypassing pan-enterovirus host factor PLA2G16.
Baggen J, Liu Y, Lyoo H, van Vliet ALW, Wahedi M, de Bruin JW, Roberts RW, Overduin P, Meijer A, Rossmann MG, Thibaut HJ, van Kuppeveld FJM. Baggen J, et al. Among authors: van vliet alw. Nat Commun. 2019 Jul 18;10(1):3171. doi: 10.1038/s41467-019-11256-z. Nat Commun. 2019. PMID: 31320648 Free PMC article.
Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association.
Rabouw HH, Visser LJ, Passchier TC, Langereis MA, Liu F, Giansanti P, van Vliet ALW, Dekker JG, van der Grein SG, Saucedo JG, Anand AA, Trellet ME, Bonvin AMJJ, Walter P, Heck AJR, de Groot RJ, van Kuppeveld FJM. Rabouw HH, et al. Among authors: van vliet alw. Nat Microbiol. 2020 Nov;5(11):1361-1373. doi: 10.1038/s41564-020-0759-0. Epub 2020 Jul 20. Nat Microbiol. 2020. PMID: 32690955
Translation and Replication Dynamics of Single RNA Viruses.
Boersma S, Rabouw HH, Bruurs LJM, Pavlovič T, van Vliet ALW, Beumer J, Clevers H, van Kuppeveld FJM, Tanenbaum ME. Boersma S, et al. Among authors: van vliet alw. Cell. 2020 Dec 23;183(7):1930-1945.e23. doi: 10.1016/j.cell.2020.10.019. Epub 2020 Nov 13. Cell. 2020. PMID: 33188777 Free PMC article.
31 results