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CXCL4 drives fibrosis by promoting several key cellular and molecular processes.
Affandi AJ, Carvalheiro T, Ottria A, de Haan JJ, Brans MAD, Brandt MM, Tieland RG, Lopes AP, Fernández BM, Bekker CPJ, van der Linden M, Zimmermann M, Giovannone B, Wichers CGK, Garcia S, de Kok M, Stifano G, Xu YJ, Kowalska MA, Waasdorp M, Cheng C, Gibbs S, de Jager SCA, van Roon JAG, Radstake TRDJ, Marut W. Affandi AJ, et al. Among authors: zimmermann m. Cell Rep. 2022 Jan 4;38(1):110189. doi: 10.1016/j.celrep.2021.110189. Cell Rep. 2022. PMID: 34986347 Free article.
Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α.
Ottria A, Zimmermann M, Paardekooper LM, Carvalheiro T, Vazirpanah N, Silva-Cardoso S, Affandi AJ, Chouri E, V D Kroef M, Tieland RG, Bekker CPJ, Wichers CGK, Rossato M, Mocholi-Gimeno E, Tekstra J, Ton E, van Laar JM, Cossu M, Beretta L, Garcia Perez S, Pandit A, Bonte-Mineur F, Reedquist KA, van den Bogaart G, Radstake TRDJ, Marut W. Ottria A, et al. Among authors: zimmermann m. Rheumatology (Oxford). 2022 May 30;61(6):2682-2693. doi: 10.1093/rheumatology/keab532. Rheumatology (Oxford). 2022. PMID: 34559222
Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren's syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?
Blokland SLM, Hillen MR, Wichers CGK, Zimmermann M, Kruize AA, Radstake TRDJ, Broen JCA, van Roon JAG. Blokland SLM, et al. Among authors: zimmermann m. RMD Open. 2019 Jan 11;5(1):e000701. doi: 10.1136/rmdopen-2018-000701. eCollection 2019. RMD Open. 2019. PMID: 30713717 Free PMC article. No abstract available.
Fatty Acid and Carnitine Metabolism Are Dysregulated in Systemic Sclerosis Patients.
Ottria A, Hoekstra AT, Zimmermann M, van der Kroef M, Vazirpanah N, Cossu M, Chouri E, Rossato M, Beretta L, Tieland RG, Wichers CGK, Stigter E, Gulersonmez C, Bonte-Mineur F, Berkers CR, Radstake TRDJ, Marut W. Ottria A, et al. Among authors: zimmermann m. Front Immunol. 2020 May 22;11:822. doi: 10.3389/fimmu.2020.00822. eCollection 2020. Front Immunol. 2020. PMID: 32528464 Free PMC article.
Angiopoietin-2 Promotes Inflammatory Activation in Monocytes of Systemic Sclerosis Patients.
Carvalheiro T, Lopes AP, van der Kroef M, Malvar-Fernandez B, Rafael-Vidal C, Hinrichs AC, Servaas NH, Bonte-Mineur F, Kok MR, Beretta L, Zimmermann M, Marut W, Pego-Reigosa JM, Radstake TRDJ, Garcia S. Carvalheiro T, et al. Among authors: zimmermann m. Int J Mol Sci. 2020 Dec 15;21(24):9544. doi: 10.3390/ijms21249544. Int J Mol Sci. 2020. PMID: 33333969 Free PMC article.
mTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: a prelude to a new add-on therapy?
Vazirpanah N, Ottria A, van der Linden M, Wichers CGK, Schuiveling M, van Lochem E, Phipps-Green A, Merriman T, Zimmermann M, Jansen M, Radstake TRDJ, Broen JCA. Vazirpanah N, et al. Among authors: zimmermann m. Ann Rheum Dis. 2019 May;78(5):663-671. doi: 10.1136/annrheumdis-2018-214656. Epub 2019 Feb 27. Ann Rheum Dis. 2019. PMID: 30814053
The International Bathymetric Chart of the Arctic Ocean Version 5.0.
Jakobsson M, Mohammad R, Karlsson M, Salas-Romero S, Vacek F, Heinze F, Bringensparr C, Castro CF, Johnson P, Kinney J, Cardigos S, Bogonko M, Accettella D, Amblas D, An L, Bohan A, Brandt A, Bünz S, Canals M, Casamor JL, Coakley B, Cornish N, Danielson S, Demarte M, Di Franco D, Dickson ML, Dorschel B, Dowdeswell JA, Dreutter S, Fremand AC, Hall JK, Hally B, Holland D, Hong JK, Ivaldi R, Knutz PC, Krawczyk DW, Kristofferson Y, Lastras G, Leck C, Lucchi RG, Masetti G, Morlighem M, Muchowski J, Nielsen T, Noormets R, Plaza-Faverola A, Prescott MM, Purser A, Rasmussen TL, Rebesco M, Rignot E, Rysgaard S, Silyakova A, Snoeijs-Leijonmalm P, Sørensen A, Straneo F, Sutherland DA, Tate AJ, Travaglini P, Trenholm N, van Wijk E, Wallace L, Willis JK, Wood M, Zimmermann M, Zinglersen KB, Mayer L. Jakobsson M, et al. Among authors: zimmermann m. Sci Data. 2024 Dec 21;11(1):1420. doi: 10.1038/s41597-024-04278-w. Sci Data. 2024. PMID: 39709502 Free PMC article.
Maintenance therapy with trofosfamide, idarubicin and etoposide in patients with rhabdomyosarcoma and other high-risk soft tissue sarcomas (CWS-2007-HR): a multicentre, open-label, randomised controlled phase 3 trial.
Koscielniak E, Ljungman G, Kazanowska B, Niggli F, Sparber-Sauer M, Handgretinger R, Zimmermann M, Boos J, Blank B, Hallmen E, Teichert von Lüttichau I, Schmid I, Fröhlich B, Müller HL, Behnisch W, Ladenstein R, Scheer M, Vokuhl C, von Kalle T, Blattmann C, Bielack S, Klingebiel T. Koscielniak E, et al. Among authors: zimmermann m. EClinicalMedicine. 2024 Nov 29;78:102957. doi: 10.1016/j.eclinm.2024.102957. eCollection 2024 Dec. EClinicalMedicine. 2024. PMID: 39687431 Free PMC article.
2,554 results