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Bone marrow NG2+/Nestin+ mesenchymal stem cells drive DTC dormancy via TGFβ2.
Nobre AR, Risson E, Singh DK, Di Martino JS, Cheung JF, Wang J, Johnson J, Russnes HG, Bravo-Cordero JJ, Birbrair A, Naume B, Azhar M, Frenette PS, Aguirre-Ghiso JA. Nobre AR, et al. Among authors: frenette ps. Nat Cancer. 2021 Mar;2(3):327-339. doi: 10.1038/s43018-021-00179-8. Epub 2021 Mar 11. Nat Cancer. 2021. PMID: 34993493 Free PMC article.
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.
Méndez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, Scadden DT, Ma'ayan A, Enikolopov GN, Frenette PS. Méndez-Ferrer S, et al. Among authors: frenette ps. Nature. 2010 Aug 12;466(7308):829-34. doi: 10.1038/nature09262. Nature. 2010. PMID: 20703299 Free PMC article.
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.
Chow A, Lucas D, Hidalgo A, Méndez-Ferrer S, Hashimoto D, Scheiermann C, Battista M, Leboeuf M, Prophete C, van Rooijen N, Tanaka M, Merad M, Frenette PS. Chow A, et al. Among authors: frenette ps. J Exp Med. 2011 Feb 14;208(2):261-71. doi: 10.1084/jem.20101688. Epub 2011 Jan 31. J Exp Med. 2011. PMID: 21282381 Free PMC article.
Arteriolar niches maintain haematopoietic stem cell quiescence.
Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, Mizoguchi T, Wei Q, Lucas D, Ito K, Mar JC, Bergman A, Frenette PS. Kunisaki Y, et al. Among authors: frenette ps. Nature. 2013 Oct 31;502(7473):637-43. doi: 10.1038/nature12612. Epub 2013 Oct 9. Nature. 2013. PMID: 24107994 Free PMC article.
187 results