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Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision.
Lewandowski D, Foik AT, Smidak R, Choi EH, Zhang J, Hoang T, Tworak A, Suh S, Leinonen H, Dong Z, Pinto AF, Tom E, Luu J, Lee J, Ma X, Bieberich E, Blackshaw S, Saghatelian A, Lyon DC, Skowronska-Krawczyk D, Tabaka M, Palczewski K. Lewandowski D, et al. JCI Insight. 2022 Feb 22;7(4):e156301. doi: 10.1172/jci.insight.156301. JCI Insight. 2022. PMID: 35015730 Free PMC article.
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition.
Luu JC, Saadane A, Leinonen H, Choi EH, Gao F, Lewandowski D, Halabi M, Sander CL, Wu A, Wang JM, Singh R, Gao S, Lessieur EM, Dong Z, Palczewska G, Mullins RF, Peachey NS, Kiser PD, Tabaka M, Kern TS, Palczewski K. Luu JC, et al. Among authors: lewandowski d. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2221045120. doi: 10.1073/pnas.2221045120. Epub 2023 May 1. Proc Natl Acad Sci U S A. 2023. PMID: 37126699 Free PMC article.
Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses.
Engfer ZJ, Lewandowski D, Dong Z, Palczewska G, Zhang J, Kordecka K, Płaczkiewicz J, Panas D, Foik AT, Tabaka M, Palczewski K. Engfer ZJ, et al. Among authors: lewandowski d. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2314698120. doi: 10.1073/pnas.2314698120. Epub 2023 Dec 8. Proc Natl Acad Sci U S A. 2023. PMID: 38064509 Free PMC article.
A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models.
Leinonen H, Zhang J, Occelli LM, Seemab U, Choi EH, L P Marinho LF, Querubin J, Kolesnikov AV, Galinska A, Kordecka K, Hoang T, Lewandowski D, Lee TT, Einstein EE, Einstein DE, Dong Z, Kiser PD, Blackshaw S, Kefalov VJ, Tabaka M, Foik A, Petersen-Jones SM, Palczewski K. Leinonen H, et al. Among authors: lewandowski d. Nat Commun. 2024 Jul 15;15(1):5943. doi: 10.1038/s41467-024-50033-5. Nat Commun. 2024. PMID: 39009597 Free PMC article.
157 results