Sieghart W - Search Results

1

α6-Containing GABA_A Receptors: Functional Roles and Therapeutic Potentials.

Sieghart W, Chiou LC, Ernst M, Fabjan J, M Savić M, Lee MT. Sieghart W, et al. Pharmacol Rev. 2022 Jan;74(1):238-270. doi: 10.1124/pharmrev.121.000293. Pharmacol Rev. 2022. PMID: 35017178 Review.

2

Cerebellar α₆ -subunit-containing GABA_A receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders.

Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mouri A, Chen LC, Treven M, Mamiya T, Fan PC, Knutson DE, Witzigmann C, Cook J, Sieghart W, Nabeshima T. Chiou LC, et al. Among authors: sieghart w. Br J Pharmacol. 2018 Jun;175(12):2414-2427. doi: 10.1111/bph.14198. Epub 2018 May 10. Br J Pharmacol. 2018. PMID: 29518821 Free PMC article.

3

The α6 subunit-containing GABA_A receptor: A novel drug target for inhibition of trigeminal activation.

Fan PC, Lai TH, Hor CC, Lee MT, Huang P, Sieghart W, Ernst M, Knutson DE, Cook J, Chiou LC. Fan PC, et al. Among authors: sieghart w. Neuropharmacology. 2018 Sep 15;140:1-13. doi: 10.1016/j.neuropharm.2018.07.017. Epub 2018 Jul 21. Neuropharmacology. 2018. PMID: 30016665 Free PMC article.

4

α6GABA_A Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia.

Tzeng HR, Lee MT, Fan PC, Knutson DE, Lai TH, Sieghart W, Cook J, Chiou LC. Tzeng HR, et al. Among authors: sieghart w. Neurotherapeutics. 2021 Jan;18(1):569-585. doi: 10.1007/s13311-020-00951-1. Epub 2020 Oct 27. Neurotherapeutics. 2021. PMID: 33111258 Free PMC article.

5

The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs.

Ramerstorfer J, Furtmüller R, Sarto-Jackson I, Varagic Z, Sieghart W, Ernst M. Ramerstorfer J, et al. Among authors: sieghart w. J Neurosci. 2011 Jan 19;31(3):870-7. doi: 10.1523/JNEUROSCI.5012-10.2011. J Neurosci. 2011. PMID: 21248110 Free PMC article.

6

Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors.

Varagic Z, Ramerstorfer J, Huang S, Rallapalli S, Sarto-Jackson I, Cook J, Sieghart W, Ernst M. Varagic Z, et al. Among authors: sieghart w. Br J Pharmacol. 2013 May;169(2):384-99. doi: 10.1111/bph.12153. Br J Pharmacol. 2013. PMID: 23472935 Free PMC article.

7

Unexpected Properties of δ-Containing GABAA Receptors in Response to Ligands Interacting with the α+ β- Site.

Mirheydari P, Ramerstorfer J, Varagic Z, Scholze P, Wimmer L, Mihovilovic MM, Sieghart W, Ernst M. Mirheydari P, et al. Among authors: sieghart w. Neurochem Res. 2014 Jun;39(6):1057-1067. doi: 10.1007/s11064-013-1156-3. Epub 2013 Sep 26. Neurochem Res. 2014. PMID: 24072672 Free PMC article.

8

Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6 GABA_A receptors.

Vasović D, Divović B, Treven M, Knutson DE, Steudle F, Scholze P, Obradović A, Fabjan J, Brković B, Sieghart W, Ernst M, Cook JM, Savić MM. Vasović D, et al. Among authors: sieghart w. Eur J Pain. 2019 May;23(5):973-984. doi: 10.1002/ejp.1365. Epub 2019 Feb 4. Eur J Pain. 2019. PMID: 30633839 Free PMC article.

9

Targeting α6GABA_A receptors as a novel therapy for schizophrenia: A proof-of-concept preclinical study using various animal models.

Lee MT, Mouri A, Kubota H, Lee HJ, Chang MH, Wu CY, Knutson DE, Mihovilovic M, Cook J, Sieghart W, Nabeshima T, Chiou LC. Lee MT, et al. Among authors: sieghart w. Biomed Pharmacother. 2022 Jun;150:113022. doi: 10.1016/j.biopha.2022.113022. Epub 2022 Apr 25. Biomed Pharmacother. 2022. PMID: 35483195 Free article.

10

A novel GABA(A) receptor pharmacology: drugs interacting with the α(+) β(-) interface.

Sieghart W, Ramerstorfer J, Sarto-Jackson I, Varagic Z, Ernst M. Sieghart W, et al. Br J Pharmacol. 2012 May;166(2):476-85. doi: 10.1111/j.1476-5381.2011.01779.x. Br J Pharmacol. 2012. PMID: 22074382 Free PMC article. Review.

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