Burke JE - Search Results

1

Precision Targeting of Mutant PI3Kα in Cancer by Selective Degradation.

Vanhaesebroeck B, Burke JE, Madsen RR. Vanhaesebroeck B, et al. Among authors: burke je. Cancer Discov. 2022 Jan;12(1):20-22. doi: 10.1158/2159-8290.CD-21-1411. Cancer Discov. 2022. PMID: 35022207 Free PMC article.

2

Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases.

Dornan GL, Burke JE. Dornan GL, et al. Among authors: burke je. Front Immunol. 2018 Mar 19;9:575. doi: 10.3389/fimmu.2018.00575. eCollection 2018. Front Immunol. 2018. PMID: 29616047 Free PMC article. Review.

3

(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase.

Rageot D, Bohnacker T, Keles E, McPhail JA, Hoffmann RM, Melone A, Borsari C, Sriramaratnam R, Sele AM, Beaufils F, Hebeisen P, Fabbro D, Hillmann P, Burke JE, Wymann MP. Rageot D, et al. Among authors: burke je. J Med Chem. 2019 Jul 11;62(13):6241-6261. doi: 10.1021/acs.jmedchem.9b00525. Epub 2019 Jun 20. J Med Chem. 2019. PMID: 31244112 Free article.

4

Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease.

Rathinaswamy MK, Burke JE. Rathinaswamy MK, et al. Among authors: burke je. Adv Biol Regul. 2020 Jan;75:100657. doi: 10.1016/j.jbior.2019.100657. Epub 2019 Sep 28. Adv Biol Regul. 2020. PMID: 31611073 Review.

5

Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections.

McPhail JA, Burke JE. McPhail JA, et al. Among authors: burke je. Adv Exp Med Biol. 2020;1274:203-222. doi: 10.1007/978-3-030-50621-6_9. Adv Exp Med Biol. 2020. PMID: 32894512 Review.

6

Rathinaswamy MK, Gaieb Z, Fleming KD, Borsari C, Harris NJ, Moeller BE, Wymann MP, Amaro RE, Burke JE. Rathinaswamy MK, et al. Among authors: burke je. Elife. 2021 Mar 4;10:e64691. doi: 10.7554/eLife.64691. Elife. 2021. PMID: 33661099 Free PMC article.

7

Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα.

Borsari C, Keles E, McPhail JA, Schaefer A, Sriramaratnam R, Goch W, Schaefer T, De Pascale M, Bal W, Gstaiger M, Burke JE, Wymann MP. Borsari C, et al. Among authors: burke je. J Am Chem Soc. 2022 Apr 13;144(14):6326-6342. doi: 10.1021/jacs.1c13568. Epub 2022 Mar 30. J Am Chem Soc. 2022. PMID: 35353516 Free PMC article.

8

Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus.

Jenkins ML, Ranga-Prasad H, Parson MAH, Harris NJ, Rathinaswamy MK, Burke JE. Jenkins ML, et al. Among authors: burke je. Nat Commun. 2023 Jan 12;14(1):181. doi: 10.1038/s41467-023-35789-6. Nat Commun. 2023. PMID: 36635288 Free PMC article.

9

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

Burke JE, Perisic O, Masson GR, Vadas O, Williams RL. Burke JE, et al. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15259-64. doi: 10.1073/pnas.1205508109. Epub 2012 Sep 4. Proc Natl Acad Sci U S A. 2012. PMID: 22949682 Free PMC article.

10

Connecting with an old partner in a new way.

Burke JE, Williams RL. Burke JE, et al. Cancer Cell. 2013 May 13;23(5):559-61. doi: 10.1016/j.ccr.2013.04.023. Cancer Cell. 2013. PMID: 23680139 Free article.

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