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BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M. Samelson AJ, et al. Among authors: kampmann m. Nat Cell Biol. 2022 Jan;24(1):24-34. doi: 10.1038/s41556-021-00821-8. Epub 2022 Jan 13. Nat Cell Biol. 2022. PMID: 35027731 Free PMC article.
Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens.
Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman JS, Cleary ML. Matheny CJ, et al. Among authors: kampmann m. Chem Biol. 2013 Nov 21;20(11):1352-63. doi: 10.1016/j.chembiol.2013.09.014. Epub 2013 Oct 31. Chem Biol. 2013. PMID: 24183972 Free PMC article.
Unraveling the mechanism of cell death induced by chemical fibrils.
Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. Julien O, et al. Among authors: kampmann m. Nat Chem Biol. 2014 Nov;10(11):969-76. doi: 10.1038/nchembio.1639. Epub 2014 Sep 28. Nat Chem Biol. 2014. PMID: 25262416 Free PMC article.
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.
Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS. Gilbert LA, et al. Among authors: kampmann m. Cell. 2014 Oct 23;159(3):647-61. doi: 10.1016/j.cell.2014.09.029. Epub 2014 Oct 9. Cell. 2014. PMID: 25307932 Free PMC article.
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. Sidrauski C, et al. Among authors: kampmann m. Elife. 2015 Apr 15;4:e07314. doi: 10.7554/eLife.07314. Elife. 2015. PMID: 25875391 Free PMC article.
178 results