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Neurodegeneration by α-synuclein-specific T cells in AAV-A53T-α-synuclein Parkinson's disease mice.
Karikari AA, McFleder RL, Ribechini E, Blum R, Bruttel V, Knorr S, Gehmeyr M, Volkmann J, Brotchie JM, Ahsan F, Haack B, Monoranu CM, Keber U, Yeghiazaryan R, Pagenstecher A, Heckel T, Bischler T, Wischhusen J, Koprich JB, Lutz MB, Ip CW. Karikari AA, et al. Among authors: brotchie jm. Brain Behav Immun. 2022 Mar;101:194-210. doi: 10.1016/j.bbi.2022.01.007. Epub 2022 Jan 12. Brain Behav Immun. 2022. PMID: 35032575 Free article.
New insights into the organization of the basal ganglia.
Koprich JB, Johnston TH, Huot P, Fox SH, Brotchie JM. Koprich JB, et al. Among authors: brotchie jm. Curr Neurol Neurosci Rep. 2009 Jul;9(4):298-304. doi: 10.1007/s11910-009-0045-2. Curr Neurol Neurosci Rep. 2009. PMID: 19515282
Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease.
Koprich JB, Johnston TH, Reyes MG, Sun X, Brotchie JM. Koprich JB, et al. Among authors: brotchie jm. Mol Neurodegener. 2010 Oct 28;5:43. doi: 10.1186/1750-1326-5-43. Mol Neurodegener. 2010. PMID: 21029459 Free PMC article.
The selective mu-opioid receptor antagonist ADL5510 reduces levodopa-induced dyskinesia without affecting antiparkinsonian action in MPTP-lesioned macaque model of Parkinson's disease.
Koprich JB, Fox SH, Johnston TH, Goodman A, Le Bourdonnec B, Dolle RE, DeHaven RN, DeHaven-Hudkins DL, Little PJ, Brotchie JM. Koprich JB, et al. Among authors: brotchie jm. Mov Disord. 2011 Jun;26(7):1225-33. doi: 10.1002/mds.23631. Epub 2011 Apr 4. Mov Disord. 2011. PMID: 21465551
213 results