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Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.
Okaniwa M, Shibata A, Ochida A, Akao Y, White KL, Shackleford DM, Duffy S, Lucantoni L, Dey S, Striepen J, Yeo T, Mok S, Aguiar ACC, Sturm A, Crespo B, Sanz LM, Churchyard A, Baum J, Pereira DB, Guido RVC, Dechering KJ, Wittlin S, Uhlemann AC, Fidock DA, Niles JC, Avery VM, Charman SA, Laleu B. Okaniwa M, et al. Among authors: guido rvc. ACS Infect Dis. 2021 Jun 11;7(6):1680-1689. doi: 10.1021/acsinfecdis.1c00020. Epub 2021 Apr 30. ACS Infect Dis. 2021. PMID: 33929818 Free PMC article.
Polyketide- and Terpenoid-Derived Metabolites Produced by a Marine-Derived Fungus, Peroneutypa sp.
de Amorim MR, Barbosa CS, Paz TA, Ióca LP, Nicácio KJ, de Oliveira LFP, Goulart MO, Paulino JM, da Cruz MO, Ferreira AG, Furlan M, de Lira SP, Dos Santos RA, Rodrigues A, Guido RVC, Berlinck RGS. de Amorim MR, et al. Among authors: guido rvc. J Nat Prod. 2023 Jun 23;86(6):1476-1486. doi: 10.1021/acs.jnatprod.3c00175. Epub 2023 Jun 8. J Nat Prod. 2023. PMID: 37289832
Structure and Biosynthesis of Perochalasins A-C, Open-Chain Merocytochalasans Produced by the Marine-Derived Fungus Peroneutypa sp. M16.
de Amorim MR, Schoellhorn SM, Barbosa CS, Mendes GR, Macedo KL, Ferreira AG, Venâncio T, Guido RVC, Batista ANL, Batista JM Jr, Skellam E, Berlinck RGS. de Amorim MR, et al. Among authors: guido rvc. J Nat Prod. 2024 Sep 27;87(9):2204-2215. doi: 10.1021/acs.jnatprod.4c00516. Epub 2024 Aug 16. J Nat Prod. 2024. PMID: 39150723 Free PMC article.
Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission.
Gomez-Gonzalez PJ, Gupta A, Drought LG, Patel A, Okombo J, van der Watt M, Walker-Gray R, Schindler KA, Burkhard AY, Yeo T, Narwal SK, Bloxham TS, Flueck C, Walker EM, Rey JA, Fairhurst KJ, Reader J, Park H, Pollard HG, Stewart LB, Brandner-Garrod L, Kristan M, Sterk GJ, van Nuland YM, Manko E, van Schalkwyk DA, Zheng Y, Leurs R, Dechering KJ, Aguiar ACC, Guido RVC, Pereira DB, Tumwebaze PK, Nosbya SL, Rosenthal PJ, Cooper RA, Palmer M, Parkinson T, Burrows JN, Uhlemann AC, Birkholtz LM, Small-Saunders JL, Duffy J, Fidock DA, Brown A, Gardner M, Baker DA. Gomez-Gonzalez PJ, et al. Among authors: guido rvc. Sci Adv. 2024 Dec 6;10(49):eadq1383. doi: 10.1126/sciadv.adq1383. Epub 2024 Dec 6. Sci Adv. 2024. PMID: 39642214 Free PMC article.
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