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Exploring the rhodanine universe: Design and synthesis of fluorescent rhodanine-based derivatives as anti-fibrillar and anti-oligomer agents against α-synuclein and 2N4R tau.
Elbatrawy AA, Ademoye TA, Alnakhala H, Tripathi A, Plascencia-Villa G, Zhu X, Perry G, Dettmer U, Fortin JS. Elbatrawy AA, et al. Among authors: alnakhala h. Bioorg Med Chem. 2024 Dec 15;116:117990. doi: 10.1016/j.bmc.2024.117990. Epub 2024 Nov 9. Bioorg Med Chem. 2024. PMID: 39550891 Free PMC article.
Evaluation of Alpha-Synuclein and Tau Antiaggregation Activity of Urea and Thiourea-Based Small Molecules for Neurodegenerative Disease Therapeutics.
Ganegamage SK, Ademoye TA, Patel H, Alnakhala H, Tripathi A, Nguyen CCD, Pham K, Plascencia-Villa G, Zhu X, Perry G, Tian S, Dettmer U, Lasagna-Reeves C, Fortin JS. Ganegamage SK, et al. Among authors: alnakhala h. ACS Chem Neurosci. 2024 Nov 6;15(21):3915-3931. doi: 10.1021/acschemneuro.4c00282. Epub 2024 Oct 22. ACS Chem Neurosci. 2024. PMID: 39436010 Free PMC article.
Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation.
Ramirez E, Ganegamage SK, Min S, Patel H, Ogunware A, Plascencia-Villa G, Alnakhala H, Shimanaka K, Tripathi A, Wang KW, Zhu X, Rochet JC, Kuo MH, Counts SE, Perry G, Dettmer U, Lasagna-Reeves CA, Fortin JS. Ramirez E, et al. Among authors: alnakhala h. ACS Chem Neurosci. 2023 Nov 1;14(21):3913-3927. doi: 10.1021/acschemneuro.3c00464. Epub 2023 Oct 11. ACS Chem Neurosci. 2023. PMID: 37818657 Free PMC article.
5-Nitro-1,2-benzothiazol-3-amine and N-Ethyl-1-[(ethylcarbamoyl)(5-nitro-1,2-benzothiazol-3-yl)amino]formamide Modulate α-Synuclein and Tau Aggregation.
Ramirez E, Ganegamage SK, Elbatrawy AA, Alnakhala H, Shimanaka K, Tripathi A, Min S, Rochet JC, Dettmer U, Fortin JS. Ramirez E, et al. Among authors: alnakhala h. ACS Omega. 2023 May 23;8(22):20102-20115. doi: 10.1021/acsomega.3c02668. eCollection 2023 Jun 6. ACS Omega. 2023. PMID: 37305264 Free PMC article.