Simpson KL - Search Results

1

A biobank of small cell lung cancer CDX models elucidates inter- and intratumoral phenotypic heterogeneity.

Simpson KL, Stoney R, Frese KK, Simms N, Rowe W, Pearce SP, Humphrey S, Booth L, Morgan D, Dynowski M, Trapani F, Catozzi A, Revill M, Helps T, Galvin M, Girard L, Nonaka D, Carter L, Krebs MG, Cook N, Carter M, Priest L, Kerr A, Gazdar AF, Blackhall F, Dive C. Simpson KL, et al. Nat Cancer. 2020 Apr;1(4):437-451. doi: 10.1038/s43018-020-0046-2. Epub 2020 Apr 13. Nat Cancer. 2020. PMID: 35121965

2

Optimisation of circulating biomarkers of cell death for routine clinical use.

Greystoke A, Cummings J, Ward T, Simpson K, Renehan A, Butt F, Moore D, Gietema J, Blackhall F, Ranson M, Hughes A, Dive C. Greystoke A, et al. Ann Oncol. 2008 May;19(5):990-5. doi: 10.1093/annonc/mdn014. Epub 2008 Feb 27. Ann Oncol. 2008. PMID: 18304966 Free article.

3

Clinical evaluation of M30 and M65 ELISA cell death assays as circulating biomarkers in a drug-sensitive tumor, testicular cancer.

de Haas EC, di Pietro A, Simpson KL, Meijer C, Suurmeijer AJ, Lancashire LJ, Cummings J, de Jong S, de Vries EG, Dive C, Gietema JA. de Haas EC, et al. Among authors: simpson kl. Neoplasia. 2008 Oct;10(10):1041-8. doi: 10.1593/neo.08620. Neoplasia. 2008. PMID: 18813353 Free PMC article.

4

Circulating biomarkers of cell death after treatment with the BH-3 mimetic ABT-737 in a preclinical model of small-cell lung cancer.

Micha D, Cummings J, Shoemaker A, Elmore S, Foster K, Greaves M, Ward T, Rosenberg S, Dive C, Simpson K. Micha D, et al. Clin Cancer Res. 2008 Nov 15;14(22):7304-10. doi: 10.1158/1078-0432.CCR-08-0111. Clin Cancer Res. 2008. PMID: 19010845 Free PMC article.

5

Quantitative mass spectrometry-based techniques for clinical use: biomarker identification and quantification.

Simpson KL, Whetton AD, Dive C. Simpson KL, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 1;877(13):1240-9. doi: 10.1016/j.jchromb.2008.11.023. Epub 2008 Nov 18. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19058768 Free PMC article. Review.

6

Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1.

Harrison LR, Micha D, Brandenburg M, Simpson KL, Morrow CJ, Denneny O, Hodgkinson C, Yunus Z, Dempsey C, Roberts D, Blackhall F, Makin G, Dive C. Harrison LR, et al. Among authors: simpson kl. J Clin Invest. 2011 Mar;121(3):1075-87. doi: 10.1172/JCI43505. J Clin Invest. 2011. PMID: 21393866 Free PMC article.

7

Is serum or plasma more appropriate for intersubject comparisons in metabolomic studies? An assessment in patients with small-cell lung cancer.

Wedge DC, Allwood JW, Dunn W, Vaughan AA, Simpson K, Brown M, Priest L, Blackhall FH, Whetton AD, Dive C, Goodacre R. Wedge DC, et al. Anal Chem. 2011 Sep 1;83(17):6689-97. doi: 10.1021/ac2012224. Epub 2011 Aug 2. Anal Chem. 2011. PMID: 21766834

8

Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery.

Zhou C, Simpson KL, Lancashire LJ, Walker MJ, Dawson MJ, Unwin RD, Rembielak A, Price P, West C, Dive C, Whetton AD. Zhou C, et al. Among authors: simpson kl. J Proteome Res. 2012 Apr 6;11(4):2103-13. doi: 10.1021/pr200636x. Epub 2012 Mar 12. J Proteome Res. 2012. PMID: 22338609 Free PMC article.

9

A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers.

Simpson KL, Cawthorne C, Zhou C, Hodgkinson CL, Walker MJ, Trapani F, Kadirvel M, Brown G, Dawson MJ, MacFarlane M, Williams KJ, Whetton AD, Dive C. Simpson KL, et al. Cell Death Dis. 2013 May 2;4(5):e613. doi: 10.1038/cddis.2013.137. Cell Death Dis. 2013. PMID: 23640455 Free PMC article.

10

Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer.

Hodgkinson CL, Morrow CJ, Li Y, Metcalf RL, Rothwell DG, Trapani F, Polanski R, Burt DJ, Simpson KL, Morris K, Pepper SD, Nonaka D, Greystoke A, Kelly P, Bola B, Krebs MG, Antonello J, Ayub M, Faulkner S, Priest L, Carter L, Tate C, Miller CJ, Blackhall F, Brady G, Dive C. Hodgkinson CL, et al. Among authors: simpson kl. Nat Med. 2014 Aug;20(8):897-903. doi: 10.1038/nm.3600. Epub 2014 Jun 1. Nat Med. 2014. PMID: 24880617

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