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BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Mac Kain A, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nunez J, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M. Samelson AJ, et al. Among authors: guo x. bioRxiv [Preprint]. 2021 Sep 20:2021.01.19.427194. doi: 10.1101/2021.01.19.427194. bioRxiv. 2021. Update in: Nat Cell Biol. 2022 Jan;24(1):24-34. doi: 10.1038/s41556-021-00821-8 PMID: 33501440 Free PMC article. Updated. Preprint.
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M. Samelson AJ, et al. Among authors: guo x. Nat Cell Biol. 2022 Jan;24(1):24-34. doi: 10.1038/s41556-021-00821-8. Epub 2022 Jan 13. Nat Cell Biol. 2022. PMID: 35027731 Free PMC article.
NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems.
Biebl MM, Delhommel F, Faust O, Zak KM, Agam G, Guo X, Mühlhofer M, Dahiya V, Hillebrand D, Popowicz GM, Kampmann M, Lamb DC, Rosenzweig R, Sattler M, Buchner J. Biebl MM, et al. Among authors: guo x. Mol Cell. 2022 Feb 3;82(3):555-569.e7. doi: 10.1016/j.molcel.2021.12.031. Epub 2022 Jan 20. Mol Cell. 2022. PMID: 35063133 Free article.
DELE1 oligomerization promotes integrated stress response activation.
Yang J, Baron KR, Pride DE, Schneemann A, Guo X, Chen W, Song AS, Aviles G, Kampmann M, Wiseman RL, Lander GC. Yang J, et al. Among authors: guo x. Nat Struct Mol Biol. 2023 Sep;30(9):1295-1302. doi: 10.1038/s41594-023-01061-0. Epub 2023 Aug 7. Nat Struct Mol Biol. 2023. PMID: 37550454 Free PMC article.
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