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Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain.
Hasegawa K, Ikeda S, Yaga M, Watanabe K, Urakawa R, Iehara A, Iwai M, Hashiguchi S, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Yoshihara S, Manabe M, Ichihara H, Mugitani A, Aoyama Y, Nakao T, Hirose A, Hino M, Ueda S, Takenaka K, Masuko T, Akashi K, Maruno T, Uchiyama S, Takamatsu S, Wada N, Morii E, Nagamori S, Motooka D, Kanai Y, Oji Y, Nakagawa T, Kijima N, Kishima H, Ikeda A, Ogino T, Shintani Y, Kubo T, Mihara E, Yusa K, Sugiyama H, Takagi J, Miyoshi E, Kumanogoh A, Hosen N. Hasegawa K, et al. Among authors: aoyama y. Sci Transl Med. 2022 Feb 16;14(632):eaax7706. doi: 10.1126/scitranslmed.aax7706. Epub 2022 Feb 16. Sci Transl Med. 2022. PMID: 35171652
CD48 as a novel molecular target for antibody therapy in multiple myeloma.
Hosen N, Ichihara H, Mugitani A, Aoyama Y, Fukuda Y, Kishida S, Matsuoka Y, Nakajima H, Kawakami M, Yamagami T, Fuji S, Tamaki H, Nakao T, Nishida S, Tsuboi A, Iida S, Hino M, Oka Y, Oji Y, Sugiyama H. Hosen N, et al. Among authors: aoyama y. Br J Haematol. 2012 Jan;156(2):213-24. doi: 10.1111/j.1365-2141.2011.08941.x. Epub 2011 Nov 21. Br J Haematol. 2012. PMID: 22098460 Free article.
The activated conformation of integrin β7 is a novel multiple myeloma-specific target for CAR T cell therapy.
Hosen N, Matsunaga Y, Hasegawa K, Matsuno H, Nakamura Y, Makita M, Watanabe K, Yoshida M, Satoh K, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Manabe M, Ichihara H, Aoyama Y, Mugitani A, Nakao T, Hino M, Uchibori R, Ozawa K, Baba Y, Terakura S, Wada N, Morii E, Nishimura J, Takeda K, Oji Y, Sugiyama H, Takagi J, Kumanogoh A. Hosen N, et al. Among authors: aoyama y. Nat Med. 2017 Dec;23(12):1436-1443. doi: 10.1038/nm.4431. Epub 2017 Nov 6. Nat Med. 2017. PMID: 29106400
CD138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients.
Hosen N, Matsuoka Y, Kishida S, Nakata J, Mizutani Y, Hasegawa K, Mugitani A, Ichihara H, Aoyama Y, Nishida S, Tsuboi A, Fujiki F, Tatsumi N, Nakajima H, Hino M, Kimura T, Yata K, Abe M, Oka Y, Oji Y, Kumanogoh A, Sugiyama H. Hosen N, et al. Among authors: aoyama y. Leukemia. 2012 Sep;26(9):2135-41. doi: 10.1038/leu.2012.80. Epub 2012 Mar 20. Leukemia. 2012. PMID: 22430638
989 results