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Page 1
Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity.
Kamerkar S, Leng C, Burenkova O, Jang SC, McCoy C, Zhang K, Dooley K, Kasera S, Zi T, Sisó S, Dahlberg W, Sia CL, Patel S, Schmidt K, Economides K, Soos T, Burzyn D, Sathyanarayanan S. Kamerkar S, et al. Among authors: economides k. Sci Adv. 2022 Feb 18;8(7):eabj7002. doi: 10.1126/sciadv.abj7002. Epub 2022 Feb 18. Sci Adv. 2022. PMID: 35179953 Free PMC article.
Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12.
Lewis ND, Sia CL, Kirwin K, Haupt S, Mahimkar G, Zi T, Xu K, Dooley K, Jang SC, Choi B, Boutin A, Grube A, McCoy C, Sanchez-Salazar J, Doherty M, Gaidukov L, Estes S, Economides KD, Williams DE, Sathyanarayanan S. Lewis ND, et al. Among authors: economides kd. Mol Cancer Ther. 2021 Mar;20(3):523-534. doi: 10.1158/1535-7163.MCT-20-0484. Epub 2020 Dec 21. Mol Cancer Ther. 2021. PMID: 33443094
ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance.
Jang SC, Economides KD, Moniz RJ, Sia CL, Lewis N, McCoy C, Zi T, Zhang K, Harrison RA, Lim J, Dey J, Grenley M, Kirwin K, Ross NL, Bourdeau R, Villiger-Oberbek A, Estes S, Xu K, Sanchez-Salazar J, Dooley K, Dahlberg WK, Williams DE, Sathyanarayanan S. Jang SC, et al. Among authors: economides kd. Commun Biol. 2021 Apr 22;4(1):497. doi: 10.1038/s42003-021-02004-5. Commun Biol. 2021. PMID: 33888863 Free PMC article.
A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties.
Dooley K, McConnell RE, Xu K, Lewis ND, Haupt S, Youniss MR, Martin S, Sia CL, McCoy C, Moniz RJ, Burenkova O, Sanchez-Salazar J, Jang SC, Choi B, Harrison RA, Houde D, Burzyn D, Leng C, Kirwin K, Ross NL, Finn JD, Gaidukov L, Economides KD, Estes S, Thornton JE, Kulman JD, Sathyanarayanan S, Williams DE. Dooley K, et al. Among authors: economides kd. Mol Ther. 2021 May 5;29(5):1729-1743. doi: 10.1016/j.ymthe.2021.01.020. Epub 2021 Jan 21. Mol Ther. 2021. PMID: 33484965 Free PMC article.
Design of BET Inhibitor Bottlebrush Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities.
Vohidov F, Andersen JN, Economides KD, Shipitsin MV, Burenkova O, Ackley JC, Vangamudi B, Nguyen HV, Gallagher NM, Shieh P, Golder MR, Liu J, Dahlberg WK, Ehrlich DJC, Kim J, Kristufek SL, Huh SJ, Neenan AM, Baddour J, Paramasivan S, de Stanchina E, Kc G, Turnquist DJ, Saucier-Sawyer JK, Kopesky PW, Brady SW, Jessel MJ, Reiter LA, Chickering DE, Johnson JA, Blume-Jensen P. Vohidov F, et al. Among authors: economides kd. J Am Chem Soc. 2021 Mar 31;143(12):4714-4724. doi: 10.1021/jacs.1c00312. Epub 2021 Mar 19. J Am Chem Soc. 2021. PMID: 33739832 Free PMC article.
Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs.
Golder MR, Liu J, Andersen JN, Shipitsin MV, Vohidov F, Nguyen HV, Ehrlich DC, Huh SJ, Vangamudi B, Economides KD, Neenan AM, Ackley JC, Baddour J, Paramasivan S, Brady SW, Held EJ, Reiter LA, Saucier-Sawyer JK, Kopesky PW, Chickering DE, Blume-Jensen P, Johnson JA. Golder MR, et al. Among authors: economides kd. Nat Biomed Eng. 2018 Nov;2(11):822-830. doi: 10.1038/s41551-018-0279-x. Epub 2018 Aug 20. Nat Biomed Eng. 2018. PMID: 30918745 Free PMC article.
Publisher Correction: Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs.
Golder MR, Liu J, Andersen JN, Shipitsin MV, Vohidov F, Nguyen HV, Ehrlich DC, Huh SJ, Vangamudi B, Economides KD, Neenan AM, Ackley JC, Baddour J, Paramasivan S, Brady SW, Held EJ, Reiter LA, Saucier-Sawyer JK, Kopesky PW, Chickering DE, Blume-Jensen P, Johnson JA. Golder MR, et al. Among authors: economides kd. Nat Biomed Eng. 2018 Sep;2(9):707. doi: 10.1038/s41551-018-0299-6. Nat Biomed Eng. 2018. PMID: 31015683
Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction.
Vasistha NA, Johnstone M, Barton SK, Mayerl SE, Thangaraj Selvaraj B, Thomson PA, Dando O, Grünewald E, Alloza C, Bastin ME, Livesey MR, Economides K, Magnani D, Makedonopolou P, Burr K, Story DJ, Blackwood DHR, Wyllie DJA, McIntosh AM, Millar JK, Ffrench-Constant C, Hardingham GE, Lawrie SM, Chandran S. Vasistha NA, et al. Among authors: economides k. Mol Psychiatry. 2019 Nov;24(11):1641-1654. doi: 10.1038/s41380-019-0505-2. Epub 2019 Sep 3. Mol Psychiatry. 2019. PMID: 31481758 Free PMC article.
23 results