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The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy.
ACS Chem Biol. 2022 Mar 18;17(3):556-566. doi: 10.1021/acschembio.1c00819. Epub 2022 Feb 21.
ACS Chem Biol. 2022.
PMID: 35188729
Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds.
Ramos AL, Goedken ER, Frank KE, Argiriadi MA, Bazzaz S, Bian Z, Brown JTC, Centrella PA, Chen HJ, Disch JS, Donner PL, Duignan DB, Gikunju D, Greszler SN, Guié MA, Habeshian S, Hartl HE, Hein CD, Hutchins CW, Jetson R, Keefe AD, Khan H, Li HQ, Olszewski A, Ortiz Cardona BJ, Osuma A, Panchal SC, Phelan R, Qiu W, Shotwell JB, Shrestha A, Srikumaran M, Su Z, Sun C, Upadhyay AK, Wood MD, Wu H, Zhang R, Zhang Y, Zhao G, Zhu H, Webster MP.
Ramos AL, et al.
J Med Chem. 2024 Apr 25;67(8):6456-6494. doi: 10.1021/acs.jmedchem.3c02397. Epub 2024 Apr 4.
J Med Chem. 2024.
PMID: 38574366
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Design and evaluation of pyrazolopyrimidines as KCNQ channel modulators.
Osuma AT, Xu X, Wang Z, Van Camp JA, Freiberg GM.
Osuma AT, et al.
Bioorg Med Chem Lett. 2019 Oct 1;29(19):126603. doi: 10.1016/j.bmcl.2019.08.007. Epub 2019 Aug 6.
Bioorg Med Chem Lett. 2019.
PMID: 31416667
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Novel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening.
Kumar A, Chettiar S, Brown BS, Early J, Ollinger J, Files M, Bailey MA, Korkegian A, Dennison D, McNeil M, Metz J, Osuma A, Curtin M, Kunzer A, Freiberg G, Bruncko M, Kempf D, Parish T.
Kumar A, et al.
Sci Rep. 2022 Sep 1;12(1):14879. doi: 10.1038/s41598-022-19192-7.
Sci Rep. 2022.
PMID: 36050506
Free PMC article.
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