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SARS-CoV-2 Variants Omicron BA.4/5 and XBB.1.5 Significantly Escape T Cell Recognition in Solid-organ Transplant Recipients Vaccinated Against the Ancestral Strain.
Halvorson T, Ivison S, Huang Q, Ladua G, Yotis DM, Mannar D, Subramaniam S, Ferreira VH, Kumar D, Belga S, Levings MK; PREVenT Study Group. Halvorson T, et al. Among authors: mannar d. Transplantation. 2024 Apr 1;108(4):e49-e62. doi: 10.1097/TP.0000000000004873. Epub 2023 Nov 28. Transplantation. 2024. PMID: 38012843
SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization.
Mannar D, Saville JW, Sun Z, Zhu X, Marti MM, Srivastava SS, Berezuk AM, Zhou S, Tuttle KS, Sobolewski MD, Kim A, Treat BR, Da Silva Castanha PM, Jacobs JL, Barratt-Boyes SM, Mellors JW, Dimitrov DS, Li W, Subramaniam S. Mannar D, et al. Nat Commun. 2022 Aug 18;13(1):4696. doi: 10.1038/s41467-022-32262-8. Nat Commun. 2022. PMID: 35982054 Free PMC article.
Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA.1 and BA.2 by biparatopic human VH domains.
Chen C, Saville JW, Marti MM, Schäfer A, Cheng MH, Mannar D, Zhu X, Berezuk AM, Banerjee A, Sobolewski MD, Kim A, Treat BR, Da Silva Castanha PM, Enick N, McCormick KD, Liu X, Adams C, Hines MG, Sun Z, Chen W, Jacobs JL, Barratt-Boyes SM, Mellors JW, Baric RS, Bahar I, Dimitrov DS, Subramaniam S, Martinez DR, Li W. Chen C, et al. Among authors: mannar d. iScience. 2022 Aug 19;25(8):104798. doi: 10.1016/j.isci.2022.104798. Epub 2022 Jul 20. iScience. 2022. PMID: 35875685 Free PMC article.
Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation.
Fraser BJ, Beldar S, Seitova A, Hutchinson A, Mannar D, Li Y, Kwon D, Tan R, Wilson RP, Leopold K, Subramaniam S, Halabelian L, Arrowsmith CH, Bénard F. Fraser BJ, et al. Among authors: mannar d. Nat Chem Biol. 2022 Sep;18(9):963-971. doi: 10.1038/s41589-022-01059-7. Epub 2022 Jun 8. Nat Chem Biol. 2022. PMID: 35676539
Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains.
Chen C, Saville JW, Marti MM, Schäfer A, Cheng MH, Mannar D, Zhu X, Berezuk AM, Banerjee A, Sobolewski MD, Kim A, Treat BR, Da Silva Castanha PM, Enick N, McCormick KD, Liu X, Adams C, Hines MG, Sun Z, Chen W, Jacobs JL, Barratt-Boyes SM, Mellors JW, Baric RS, Bahar I, Dimitrov DS, Subramaniam S, Martinez DR, Li W. Chen C, et al. Among authors: mannar d. bioRxiv [Preprint]. 2022 Feb 24:2022.02.18.481058. doi: 10.1101/2022.02.18.481058. bioRxiv. 2022. Update in: iScience. 2022 Aug 19;25(8):104798. doi: 10.1016/j.isci.2022.104798 PMID: 35194603 Free PMC article. Updated. Preprint.
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