Yu X - Search Results

1

EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis.

Wang J, Yu X, Gong W, Liu X, Park KS, Ma A, Tsai YH, Shen Y, Onikubo T, Pi WC, Allison DF, Liu J, Chen WY, Cai L, Roeder RG, Jin J, Wang GG. Wang J, et al. Among authors: yu x. Nat Cell Biol. 2022 Mar;24(3):384-399. doi: 10.1038/s41556-022-00850-x. Epub 2022 Feb 24. Nat Cell Biol. 2022. PMID: 35210568 Free PMC article.

2

Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D₁ Receptor Agonists.

Martini ML, Liu J, Ray C, Yu X, Huang XP, Urs A, Urs N, McCorvy JD, Caron MG, Roth BL, Jin J. Martini ML, et al. Among authors: yu x. J Med Chem. 2019 Apr 11;62(7):3753-3772. doi: 10.1021/acs.jmedchem.9b00351. Epub 2019 Mar 27. J Med Chem. 2019. PMID: 30875219 Free PMC article.

3

Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68).

Yu X, Huang XP, Kenakin TP, Slocum ST, Chen X, Martini ML, Liu J, Jin J. Yu X, et al. J Med Chem. 2019 Aug 22;62(16):7557-7574. doi: 10.1021/acs.jmedchem.9b00869. Epub 2019 Aug 1. J Med Chem. 2019. PMID: 31298539 Free PMC article.

4

Designing Functionally Selective Noncatechol Dopamine D₁ Receptor Agonists with Potent In Vivo Antiparkinsonian Activity.

Martini ML, Ray C, Yu X, Liu J, Pogorelov VM, Wetsel WC, Huang XP, McCorvy JD, Caron MG, Jin J. Martini ML, et al. Among authors: yu x. ACS Chem Neurosci. 2019 Sep 18;10(9):4160-4182. doi: 10.1021/acschemneuro.9b00410. Epub 2019 Aug 20. ACS Chem Neurosci. 2019. PMID: 31387346 Free PMC article.

5

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism.

Bott AJ, Shen J, Tonelli C, Zhan L, Sivaram N, Jiang YP, Yu X, Bhatt V, Chiles E, Zhong H, Maimouni S, Dai W, Velasquez S, Pan JA, Muthalagu N, Morton J, Anthony TG, Feng H, Lamers WH, Murphy DJ, Guo JY, Jin J, Crawford HC, Zhang L, White E, Lin RZ, Su X, Tuveson DA, Zong WX. Bott AJ, et al. Among authors: yu x. Cell Rep. 2019 Oct 29;29(5):1287-1298.e6. doi: 10.1016/j.celrep.2019.09.056. Cell Rep. 2019. PMID: 31665640 Free PMC article.

6

Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery.

Chiarella AM, Butler KV, Gryder BE, Lu D, Wang TA, Yu X, Pomella S, Khan J, Jin J, Hathaway NA. Chiarella AM, et al. Among authors: yu x. Nat Biotechnol. 2020 Jan;38(1):50-55. doi: 10.1038/s41587-019-0296-7. Epub 2019 Nov 11. Nat Biotechnol. 2020. PMID: 31712774 Free PMC article.

7

Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders.

Cheng M, Yu X, Lu K, Xie L, Wang L, Meng F, Han X, Chen X, Liu J, Xiong Y, Jin J. Cheng M, et al. Among authors: yu x. J Med Chem. 2020 Feb 13;63(3):1216-1232. doi: 10.1021/acs.jmedchem.9b01566. Epub 2020 Jan 14. J Med Chem. 2020. PMID: 31895569 Free PMC article.

8

Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders.

Shen Y, Gao G, Yu X, Kim H, Wang L, Xie L, Schwarz M, Chen X, Guccione E, Liu J, Bedford MT, Jin J. Shen Y, et al. Among authors: yu x. J Med Chem. 2020 Sep 10;63(17):9977-9989. doi: 10.1021/acs.jmedchem.0c01111. Epub 2020 Aug 21. J Med Chem. 2020. PMID: 32787082 Free PMC article.

9

ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism.

Li J, Galbo PM Jr, Gong W, Storey AJ, Tsai YH, Yu X, Ahn JH, Guo Y, Mackintosh SG, Edmondson RD, Byrum SD, Farrar JE, He S, Cai L, Jin J, Tackett AJ, Zheng D, Wang GG. Li J, et al. Among authors: yu x. Nat Commun. 2021 Feb 16;12(1):1045. doi: 10.1038/s41467-021-21357-3. Nat Commun. 2021. PMID: 33594072 Free PMC article.

10

Inhibition of EZH2 primes the cardiac gene activation via removal of epigenetic repression during human direct cardiac reprogramming.

Tang Y, Zhao L, Yu X, Zhang J, Qian L, Jin J, Lu R, Zhou Y. Tang Y, et al. Among authors: yu x. Stem Cell Res. 2021 May;53:102365. doi: 10.1016/j.scr.2021.102365. Epub 2021 Apr 27. Stem Cell Res. 2021. PMID: 34087994 Free PMC article.

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