Tyndall JDA - Search Results

1

Improving Antibacterial Activity of a HtrA Protease Inhibitor JO146 against Helicobacter pylori: A Novel Approach Using Microfluidics-Engineered PLGA Nanoparticles.

Hwang J, Mros S, Gamble AB, Tyndall JDA, McDowell A. Hwang J, et al. Among authors: tyndall jda. Pharmaceutics. 2022 Feb 1;14(2):348. doi: 10.3390/pharmaceutics14020348. Pharmaceutics. 2022. PMID: 35214080 Free PMC article.

2

Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor.

Spencer ES, Dale EJ, Gommans AL, Rutledge MT, Vo CT, Nakatani Y, Gamble AB, Smith RA, Wilbanks SM, Hampton MB, Tyndall JD. Spencer ES, et al. Eur J Med Chem. 2015 Mar 26;93:501-10. doi: 10.1016/j.ejmech.2015.02.012. Epub 2015 Feb 24. Eur J Med Chem. 2015. PMID: 25743213

3

Stability, Kinetic, and Mechanistic Investigation of 1,8-Self-Immolative Cinnamyl Ether Spacers for Controlled Release of Phenols and Generation of Resonance and Inductively Stabilized Methides.

Matikonda SS, Fairhall JM, Tyndall JD, Hook S, Gamble AB. Matikonda SS, et al. Org Lett. 2017 Feb 3;19(3):528-531. doi: 10.1021/acs.orglett.6b03695. Epub 2017 Jan 12. Org Lett. 2017. PMID: 28080067

4

Proteases and protease inhibitors in infectious diseases.

Agbowuro AA, Huston WM, Gamble AB, Tyndall JDA. Agbowuro AA, et al. Among authors: tyndall jda. Med Res Rev. 2018 Jul;38(4):1295-1331. doi: 10.1002/med.21475. Epub 2017 Nov 17. Med Res Rev. 2018. PMID: 29149530 Review.

5

Structure-activity analysis of peptidic Chlamydia HtrA inhibitors.

Agbowuro AA, Hwang J, Peel E, Mazraani R, Springwald A, Marsh JW, McCaughey L, Gamble AB, Huston WM, Tyndall JDA. Agbowuro AA, et al. Among authors: tyndall jda. Bioorg Med Chem. 2019 Sep 15;27(18):4185-4199. doi: 10.1016/j.bmc.2019.07.049. Epub 2019 Jul 30. Bioorg Med Chem. 2019. PMID: 31395511

6

Optimization of peptide-based inhibitors targeting the HtrA serine protease in Chlamydia: Design, synthesis and biological evaluation of pyridone-based and N-Capping group-modified analogues.

Hwang J, Strange N, Phillips MJA, Krause AL, Heywood A, Gamble AB, Huston WM, Tyndall JDA. Hwang J, et al. Among authors: tyndall jda. Eur J Med Chem. 2021 Nov 15;224:113692. doi: 10.1016/j.ejmech.2021.113692. Epub 2021 Jul 7. Eur J Med Chem. 2021. PMID: 34265463

7

Design, synthesis and biological evaluation of P2-modified proline analogues targeting the HtrA serine protease in Chlamydia.

Hwang J, Strange N, Mazraani R, Phillips MJ, Gamble AB, Huston WM, Tyndall JDA. Hwang J, et al. Among authors: tyndall jda. Eur J Med Chem. 2022 Feb 15;230:114064. doi: 10.1016/j.ejmech.2021.114064. Epub 2021 Dec 31. Eur J Med Chem. 2022. PMID: 35007862

8

Synthesis and Biological Evaluation of Aurachin D Analogues as Inhibitors of Mycobacterium tuberculosis Cytochrome bd Oxidase.

Lawer A, Tyler C, Hards K, Keighley LM, Cheung CY, Kierek F, Su S, Matikonda SS, McInnes T, Tyndall JDA, Krause KL, Cook GM, Gamble AB. Lawer A, et al. Among authors: tyndall jda. ACS Med Chem Lett. 2022 Sep 26;13(10):1663-1669. doi: 10.1021/acsmedchemlett.2c00401. eCollection 2022 Oct 13. ACS Med Chem Lett. 2022. PMID: 36262396 Free PMC article.

9

Chlamydia Serine Protease Inhibitor, targeting HtrA, as a New Treatment for Koala Chlamydia infection.

Lawrence A, Fraser T, Gillett A, Tyndall JD, Timms P, Polkinghorne A, Huston WM. Lawrence A, et al. Sci Rep. 2016 Aug 17;6:31466. doi: 10.1038/srep31466. Sci Rep. 2016. PMID: 27530689 Free PMC article.

10

S-217622, a 3CL Protease Inhibitor and Clinical Candidate for SARS-CoV-2.

Tyndall JDA. Tyndall JDA. J Med Chem. 2022 May 12;65(9):6496-6498. doi: 10.1021/acs.jmedchem.2c00624. Epub 2022 May 4. J Med Chem. 2022. PMID: 35507419

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