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Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists.
Gillis A, Gondin AB, Kliewer A, Sanchez J, Lim HD, Alamein C, Manandhar P, Santiago M, Fritzwanker S, Schmiedel F, Katte TA, Reekie T, Grimsey NL, Kassiou M, Kellam B, Krasel C, Halls ML, Connor M, Lane JR, Schulz S, Christie MJ, Canals M. Gillis A, et al. Among authors: lim hd. Sci Signal. 2020 Mar 31;13(625):eaaz3140. doi: 10.1126/scisignal.aaz3140. Sci Signal. 2020. PMID: 32234959
Identification and Characterization of ML321: A Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity.
Free RB, Nilson AN, Boldizsar NM, Doyle TB, Rodriguiz RM, Pogorelov VM, Machino M, Lee KH, Bertz JW, Xu J, Lim HD, Dulcey AE, Mach RH, Woods JH, Lane JR, Shi L, Marugan JJ, Wetsel WC, Sibley DR. Free RB, et al. Among authors: lim hd. ACS Pharmacol Transl Sci. 2022 Dec 30;6(1):151-170. doi: 10.1021/acsptsci.2c00202. eCollection 2023 Jan 13. ACS Pharmacol Transl Sci. 2022. PMID: 36654757 Free PMC article.
88 results