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Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells.
Toledo CM, Ding Y, Hoellerbauer P, Davis RJ, Basom R, Girard EJ, Lee E, Corrin P, Hart T, Bolouri H, Davison J, Zhang Q, Hardcastle J, Aronow BJ, Plaisier CL, Baliga NS, Moffat J, Lin Q, Li XN, Nam DH, Lee J, Pollard SM, Zhu J, Delrow JJ, Clurman BE, Olson JM, Paddison PJ. Toledo CM, et al. Among authors: paddison pj. Cell Rep. 2015 Dec 22;13(11):2425-2439. doi: 10.1016/j.celrep.2015.11.021. Epub 2015 Dec 7. Cell Rep. 2015. PMID: 26673326 Free PMC article.
Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.
Davis RJ, Gönen M, Margineantu DH, Handeli S, Swanger J, Hoellerbauer P, Paddison PJ, Gu H, Raftery D, Grim JE, Hockenbery DM, Margolin AA, Clurman BE. Davis RJ, et al. Among authors: paddison pj. Proc Natl Acad Sci U S A. 2018 May 22;115(21):5462-5467. doi: 10.1073/pnas.1718338115. Epub 2018 May 7. Proc Natl Acad Sci U S A. 2018. PMID: 29735700 Free PMC article.
Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma.
O'Connor SA, Feldman HM, Arora S, Hoellerbauer P, Toledo CM, Corrin P, Carter L, Kufeld M, Bolouri H, Basom R, Delrow J, McFaline-Figueroa JL, Trapnell C, Pollard SM, Patel A, Paddison PJ, Plaisier CL. O'Connor SA, et al. Among authors: paddison pj. Mol Syst Biol. 2021 Jun;17(6):e9522. doi: 10.15252/msb.20209522. Mol Syst Biol. 2021. PMID: 34101353 Free PMC article.
Hyper-active RAS/MAPK introduces cancer-specific mitotic vulnerabilities.
Herman JA, Romain RR, Hoellerbauer P, Shirnekhi HK, King DC, DeLuca KF, Osborne Nishimura E, Paddison PJ, DeLuca JG. Herman JA, et al. Among authors: paddison pj. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2208255119. doi: 10.1073/pnas.2208255119. Epub 2022 Oct 3. Proc Natl Acad Sci U S A. 2022. PMID: 36191188 Free PMC article.
Cancer-Specific requirement for BUB1B/BUBR1 in human brain tumor isolates and genetically transformed cells.
Ding Y, Hubert CG, Herman J, Corrin P, Toledo CM, Skutt-Kakaria K, Vazquez J, Basom R, Zhang B, Risler JK, Pollard SM, Nam DH, Delrow JJ, Zhu J, Lee J, DeLuca J, Olson JM, Paddison PJ. Ding Y, et al. Among authors: paddison pj. Cancer Discov. 2013 Feb;3(2):198-211. doi: 10.1158/2159-8290.CD-12-0353. Epub 2012 Nov 15. Cancer Discov. 2013. PMID: 23154965 Free PMC article.
Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression.
Sripathy S, Leko V, Adrianse RL, Loe T, Foss EJ, Dalrymple E, Lao U, Gatbonton-Schwager T, Carter KT, Payer B, Paddison PJ, Grady WM, Lee JT, Bartolomei MS, Bedalov A. Sripathy S, et al. Among authors: paddison pj. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1619-1624. doi: 10.1073/pnas.1621356114. Epub 2017 Jan 31. Proc Natl Acad Sci U S A. 2017. PMID: 28143937 Free PMC article.
63 results