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A phase 2a randomized vehicle-controlled multi-center study of the safety and efficacy of delgocitinib in subjects with moderate-to-severe alopecia areata.
Mikhaylov D, Glickman JW, Del Duca E, Nia J, Hashim P, Singer GK, Posligua AL, Florek AG, Ibler E, Hagstrom EL, Estrada Y, Rangel SM, Colavincenzo M, Paller AS, Guttman-Yassky E. Mikhaylov D, et al. Among authors: paller as. Arch Dermatol Res. 2023 Mar;315(2):181-189. doi: 10.1007/s00403-022-02336-0. Epub 2022 Mar 1. Arch Dermatol Res. 2023. PMID: 35230488 Clinical Trial.
Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)(+) TH2/TH1 cell imbalance, whereas adults acquire CLA(+) TH22/TC22 cell subsets.
Czarnowicki T, Esaki H, Gonzalez J, Malajian D, Shemer A, Noda S, Talasila S, Berry A, Gray J, Becker L, Estrada Y, Xu H, Zheng X, Suárez-Fariñas M, Krueger JG, Paller AS, Guttman-Yassky E. Czarnowicki T, et al. Among authors: paller as. J Allergy Clin Immunol. 2015 Oct;136(4):941-951.e3. doi: 10.1016/j.jaci.2015.05.049. Epub 2015 Aug 1. J Allergy Clin Immunol. 2015. PMID: 26242300 Free PMC article.
Accelerated T-cell activation and differentiation of polar subsets characterizes early atopic dermatitis development.
Esaki H, Czarnowicki T, Gonzalez J, Oliva M, Talasila S, Haugh I, Rodriguez G, Becker L, Krueger JG, Guttman-Yassky E, Paller AS. Esaki H, et al. Among authors: paller as. J Allergy Clin Immunol. 2016 Nov;138(5):1473-1477.e5. doi: 10.1016/j.jaci.2016.04.052. Epub 2016 Jun 16. J Allergy Clin Immunol. 2016. PMID: 27450726 No abstract available.
An IL-17-dominant immune profile is shared across the major orphan forms of ichthyosis.
Paller AS, Renert-Yuval Y, Suprun M, Esaki H, Oliva M, Huynh TN, Ungar B, Kunjravia N, Friedland R, Peng X, Zheng X, Estrada YD, Krueger JG, Choate KA, Suárez-Fariñas M, Guttman-Yassky E. Paller AS, et al. J Allergy Clin Immunol. 2017 Jan;139(1):152-165. doi: 10.1016/j.jaci.2016.07.019. Epub 2016 Aug 20. J Allergy Clin Immunol. 2017. PMID: 27554821 Free PMC article.
Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin.
Esaki H, Brunner PM, Renert-Yuval Y, Czarnowicki T, Huynh T, Tran G, Lyon S, Rodriguez G, Immaneni S, Johnson DB, Bauer B, Fuentes-Duculan J, Zheng X, Peng X, Estrada YD, Xu H, de Guzman Strong C, Suárez-Fariñas M, Krueger JG, Paller AS, Guttman-Yassky E. Esaki H, et al. Among authors: paller as. J Allergy Clin Immunol. 2016 Dec;138(6):1639-1651. doi: 10.1016/j.jaci.2016.07.013. Epub 2016 Sep 23. J Allergy Clin Immunol. 2016. PMID: 27671162
Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder.
Brunner PM, Silverberg JI, Guttman-Yassky E, Paller AS, Kabashima K, Amagai M, Luger TA, Deleuran M, Werfel T, Eyerich K, Stingl G; Councilors of the International Eczema Council. Brunner PM, et al. Among authors: paller as. J Invest Dermatol. 2017 Jan;137(1):18-25. doi: 10.1016/j.jid.2016.08.022. Epub 2016 Oct 20. J Invest Dermatol. 2017. PMID: 27771048 Free article. Review.
Alterations in B-cell subsets in pediatric patients with early atopic dermatitis.
Czarnowicki T, Esaki H, Gonzalez J, Renert-Yuval Y, Brunner P, Oliva M, Estrada Y, Xu H, Zheng X, Talasila S, Haugh I, Huynh T, Lyon S, Tran G, Sampson H, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E, Paller AS. Czarnowicki T, et al. Among authors: paller as. J Allergy Clin Immunol. 2017 Jul;140(1):134-144.e9. doi: 10.1016/j.jaci.2016.09.060. Epub 2016 Dec 10. J Allergy Clin Immunol. 2017. PMID: 27965110
Expert Perspectives on Management of Moderate-to-Severe Atopic Dermatitis: A Multidisciplinary Consensus Addressing Current and Emerging Therapies.
Boguniewicz M, Alexis AF, Beck LA, Block J, Eichenfield LF, Fonacier L, Guttman-Yassky E, Paller AS, Pariser D, Silverberg JI, Lebwohl M. Boguniewicz M, et al. Among authors: paller as. J Allergy Clin Immunol Pract. 2017 Nov-Dec;5(6):1519-1531. doi: 10.1016/j.jaip.2017.08.005. Epub 2017 Sep 29. J Allergy Clin Immunol Pract. 2017. PMID: 28970084 Free article. Review.
The Major Orphan Forms of Ichthyosis Are Characterized by Systemic T-Cell Activation and Th-17/Tc-17/Th-22/Tc-22 Polarization in Blood.
Czarnowicki T, He H, Leonard A, Malik K, Magidi S, Rangel S, Patel K, Ramsey K, Murphrey M, Song T, Estrada Y, Wen HC, Krueger JG, Guttman-Yassky E, Paller AS. Czarnowicki T, et al. Among authors: paller as. J Invest Dermatol. 2018 Oct;138(10):2157-2167. doi: 10.1016/j.jid.2018.03.1523. Epub 2018 Apr 14. J Invest Dermatol. 2018. PMID: 29660300 Free article.
660 results