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A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation.
Hansen JN, Kaiser F, Leyendecker P, Stüven B, Krause JH, Derakhshandeh F, Irfan J, Sroka TJ, Preval KM, Desai PB, Kraut M, Theis H, Drews AD, De-Domenico E, Händler K, Pazour GJ, Henderson DJP, Mick DU, Wachten D. Hansen JN, et al. Among authors: preval km. EMBO Rep. 2022 Aug 3;23(8):e54315. doi: 10.15252/embr.202154315. Epub 2022 Jun 13. EMBO Rep. 2022. PMID: 35695071 Free PMC article.
The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in pre-cystic epithelial cells revealing a new target for polycystic kidney disease.
Smith AO, Frantz WT, Preval KM, Edwards YJK, Ceol CJ, Jonassen JA, Pazour GJ. Smith AO, et al. Among authors: preval km. medRxiv [Preprint]. 2023 Dec 4:2023.12.04.23299387. doi: 10.1101/2023.12.04.23299387. medRxiv. 2023. Update in: PLoS Genet. 2024 Dec 12;20(12):e1011510. doi: 10.1371/journal.pgen.1011510 PMID: 38106222 Free PMC article. Updated. Preprint.