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Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses.
Chen LL, Morcelle C, Cheng ZL, Chen X, Xu Y, Gao Y, Song J, Li Z, Smith MD, Shi M, Zhu Y, Zhou N, Cheng M, He C, Liu KY, Lu G, Zhang L, Zhang C, Zhang J, Sun Y, Qi T, Lyu Y, Ren ZZ, Tan XM, Yin J, Lan F, Liu Y, Yang H, Qian M, Duan C, Chang X, Zhou Y, Shen L, Baldwin AS, Guan KL, Xiong Y, Ye D. Chen LL, et al. Among authors: chang x. Nat Cell Biol. 2022 Mar;24(3):353-363. doi: 10.1038/s41556-022-00853-8. Epub 2022 Mar 7. Nat Cell Biol. 2022. PMID: 35256775 Free PMC article.
Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction.
Jia XE, Ma K, Xu T, Gao L, Wu S, Fu C, Zhang W, Wang Z, Liu K, Dong M, Jing C, Ren C, Dong Z, Chen Y, Jin Y, Huang Q, Chang X, Deng M, Li L, Luo L, Zhu J, Dang Y, Chang HC, Zon LI, Zhou Y, Chen S, Pan W. Jia XE, et al. Among authors: chang x, chang hc. Cell Res. 2015 Aug;25(8):946-62. doi: 10.1038/cr.2015.81. Epub 2015 Jul 3. Cell Res. 2015. PMID: 26138676 Free PMC article.
KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype.
Zhang B, Long Q, Wu S, Xu Q, Song S, Han L, Qian M, Ren X, Liu H, Jiang J, Guo J, Zhang X, Chang X, Fu Q, Lam EW, Campisi J, Kirkland JL, Sun Y. Zhang B, et al. Among authors: chang x. Nat Aging. 2021 May;1(5):454-472. doi: 10.1038/s43587-021-00063-1. Epub 2021 May 13. Nat Aging. 2021. Retraction in: Nat Aging. 2024 Dec;4(12):1898. doi: 10.1038/s43587-024-00749-2 PMID: 34263179 Free PMC article. Retracted.
4,889 results