Yang H - Search Results

1

Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses.

Chen LL, Morcelle C, Cheng ZL, Chen X, Xu Y, Gao Y, Song J, Li Z, Smith MD, Shi M, Zhu Y, Zhou N, Cheng M, He C, Liu KY, Lu G, Zhang L, Zhang C, Zhang J, Sun Y, Qi T, Lyu Y, Ren ZZ, Tan XM, Yin J, Lan F, Liu Y, Yang H, Qian M, Duan C, Chang X, Zhou Y, Shen L, Baldwin AS, Guan KL, Xiong Y, Ye D. Chen LL, et al. Among authors: yang h. Nat Cell Biol. 2022 Mar;24(3):353-363. doi: 10.1038/s41556-022-00853-8. Epub 2022 Mar 7. Nat Cell Biol. 2022. PMID: 35256775 Free PMC article.

2

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.

Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu LX, Jiang WQ, Liu J, Zhang JY, Wang B, Frye S, Zhang Y, Xu YH, Lei QY, Guan KL, Zhao SM, Xiong Y. Xu W, et al. Among authors: yang c, yang h, yang y. Cancer Cell. 2011 Jan 18;19(1):17-30. doi: 10.1016/j.ccr.2010.12.014. Cancer Cell. 2011. PMID: 21251613 Free PMC article.

3

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.

Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D, Xiong Y, Guan KL. Xiao M, et al. Among authors: yang c, yang h. Genes Dev. 2012 Jun 15;26(12):1326-38. doi: 10.1101/gad.191056.112. Epub 2012 Jun 7. Genes Dev. 2012. PMID: 22677546 Free PMC article.

4

IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives.

Yang H, Ye D, Guan KL, Xiong Y. Yang H, et al. Clin Cancer Res. 2012 Oct 15;18(20):5562-71. doi: 10.1158/1078-0432.CCR-12-1773. Clin Cancer Res. 2012. PMID: 23071358 Free PMC article. Review.

5

Metabolic alteration in tumorigenesis.

Yang H, Xiong Y, Guan K. Yang H, et al. Sci China Life Sci. 2013 Dec;56(12):1067-75. doi: 10.1007/s11427-013-4549-2. Epub 2013 Oct 10. Sci China Life Sci. 2013. PMID: 24114443 Review.

6

TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites.

Yang H, Lin H, Xu H, Zhang L, Cheng L, Wen B, Shou J, Guan K, Xiong Y, Ye D. Yang H, et al. Cell Res. 2014 Aug;24(8):1017-20. doi: 10.1038/cr.2014.81. Epub 2014 Jun 27. Cell Res. 2014. PMID: 24971736 Free PMC article. No abstract available.

7

WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation.

Wang Y, Xiao M, Chen X, Chen L, Xu Y, Lv L, Wang P, Yang H, Ma S, Lin H, Jiao B, Ren R, Ye D, Guan KL, Xiong Y. Wang Y, et al. Among authors: yang h. Mol Cell. 2015 Feb 19;57(4):662-673. doi: 10.1016/j.molcel.2014.12.023. Epub 2015 Jan 15. Mol Cell. 2015. PMID: 25601757 Free PMC article.

8

SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth.

Yang H, Zhou L, Shi Q, Zhao Y, Lin H, Zhang M, Zhao S, Yang Y, Ling ZQ, Guan KL, Xiong Y, Ye D. Yang H, et al. Among authors: yang y. EMBO J. 2015 Apr 15;34(8):1110-25. doi: 10.15252/embj.201591041. Epub 2015 Mar 9. EMBO J. 2015. PMID: 25755250 Free PMC article.

9

D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth.

Ma S, Jiang B, Deng W, Gu ZK, Wu FZ, Li T, Xia Y, Yang H, Ye D, Xiong Y, Guan KL. Ma S, et al. Among authors: yang h. Oncotarget. 2015 Apr 20;6(11):8606-20. doi: 10.18632/oncotarget.3330. Oncotarget. 2015. PMID: 25825982 Free PMC article.

10

Corrigendum: inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.

Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D, Xiong Y, Guan KL. Xiao M, et al. Among authors: yang c, yang h. Genes Dev. 2015 Apr 15;29(8):887. Epub 2015 Apr 15. Genes Dev. 2015. PMID: 25877923 Free PMC article. No abstract available.

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