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Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration.
Vest RT, Chou CC, Zhang H, Haney MS, Li L, Laqtom NN, Chang B, Shuken S, Nguyen A, Yerra L, Yang AC, Green C, Tanga M, Abu-Remaileh M, Bassik MC, Frydman J, Luo J, Wyss-Coray T. Vest RT, et al. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2121609119. doi: 10.1073/pnas.2121609119. Epub 2022 Mar 8. Proc Natl Acad Sci U S A. 2022. PMID: 35259016 Free PMC article.
Physiological blood-brain transport is impaired with age by a shift in transcytosis.
Yang AC, Stevens MY, Chen MB, Lee DP, Stähli D, Gate D, Contrepois K, Chen W, Iram T, Zhang L, Vest RT, Chaney A, Lehallier B, Olsson N, du Bois H, Hsieh R, Cropper HC, Berdnik D, Li L, Wang EY, Traber GM, Bertozzi CR, Luo J, Snyder MP, Elias JE, Quake SR, James ML, Wyss-Coray T. Yang AC, et al. Among authors: vest rt. Nature. 2020 Jul;583(7816):425-430. doi: 10.1038/s41586-020-2453-z. Epub 2020 Jul 1. Nature. 2020. PMID: 32612231 Free PMC article.
Dysregulation of brain and choroid plexus cell types in severe COVID-19.
Yang AC, Kern F, Losada PM, Agam MR, Maat CA, Schmartz GP, Fehlmann T, Stein JA, Schaum N, Lee DP, Calcuttawala K, Vest RT, Berdnik D, Lu N, Hahn O, Gate D, McNerney MW, Channappa D, Cobos I, Ludwig N, Schulz-Schaeffer WJ, Keller A, Wyss-Coray T. Yang AC, et al. Among authors: vest rt. Nature. 2021 Jul;595(7868):565-571. doi: 10.1038/s41586-021-03710-0. Epub 2021 Jun 21. Nature. 2021. PMID: 34153974 Free PMC article.
Publisher Correction: Dysregulation of brain and choroid plexus cell types in severe COVID-19.
Yang AC, Kern F, Losada PM, Agam MR, Maat CA, Schmartz GP, Fehlmann T, Stein JA, Schaum N, Lee DP, Calcuttawala K, Vest RT, Berdnik D, Lu N, Hahn O, Gate D, McNerney MW, Channappa D, Cobos I, Ludwig N, Schulz-Schaeffer WJ, Keller A, Wyss-Coray T. Yang AC, et al. Among authors: vest rt. Nature. 2021 Oct;598(7882):E4. doi: 10.1038/s41586-021-04080-3. Nature. 2021. PMID: 34625744 Free PMC article. No abstract available.
Exercise plasma boosts memory and dampens brain inflammation via clusterin.
De Miguel Z, Khoury N, Betley MJ, Lehallier B, Willoughby D, Olsson N, Yang AC, Hahn O, Lu N, Vest RT, Bonanno LN, Yerra L, Zhang L, Saw NL, Fairchild JK, Lee D, Zhang H, McAlpine PL, Contrepois K, Shamloo M, Elias JE, Rando TA, Wyss-Coray T. De Miguel Z, et al. Among authors: vest rt. Nature. 2021 Dec;600(7889):494-499. doi: 10.1038/s41586-021-04183-x. Epub 2021 Dec 8. Nature. 2021. PMID: 34880498 Free PMC article.
A human brain vascular atlas reveals diverse mediators of Alzheimer's risk.
Yang AC, Vest RT, Kern F, Lee DP, Agam M, Maat CA, Losada PM, Chen MB, Schaum N, Khoury N, Toland A, Calcuttawala K, Shin H, Pálovics R, Shin A, Wang EY, Luo J, Gate D, Schulz-Schaeffer WJ, Chu P, Siegenthaler JA, McNerney MW, Keller A, Wyss-Coray T. Yang AC, et al. Among authors: vest rt. Nature. 2022 Mar;603(7903):885-892. doi: 10.1038/s41586-021-04369-3. Epub 2022 Feb 14. Nature. 2022. PMID: 35165441 Free PMC article.
Proteostasis and lysosomal quality control deficits in Alzheimer's disease neurons.
Chou CC, Vest R, Prado MA, Wilson-Grady J, Paulo JA, Shibuya Y, Moran-Losada P, Lee TT, Luo J, Gygi SP, Kelly JW, Finley D, Wernig M, Wyss-Coray T, Frydman J. Chou CC, et al. bioRxiv [Preprint]. 2023 Mar 27:2023.03.27.534444. doi: 10.1101/2023.03.27.534444. bioRxiv. 2023. PMID: 37034684 Free PMC article. Preprint.
13 results