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Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication.
Kerr CM, Pfannenstiel JJ, Alhammad YM, O'Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Kerr CM, et al. Among authors: alhammad ym. J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24. Epub 2024 Oct 10. J Virol. 2024. PMID: 39387584 Free article.
Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection.
Kerr CM, Pfannenstiel JJ, Alhammad YM, O'Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Kerr CM, et al. Among authors: alhammad ym. bioRxiv [Preprint]. 2024 Jul 12:2024.01.03.574082. doi: 10.1101/2024.01.03.574082. bioRxiv. 2024. Update in: J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24 PMID: 38260573 Free PMC article. Updated. Preprint.
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice.
Alhammad YM, Parthasarathy S, Ghimire R, Kerr CM, O'Connor JJ, Pfannenstiel JJ, Chanda D, Miller CA, Baumlin N, Salathe M, Unckless RL, Zuñiga S, Enjuanes L, More S, Channappanavar R, Fehr AR. Alhammad YM, et al. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2302083120. doi: 10.1073/pnas.2302083120. Epub 2023 Aug 22. Proc Natl Acad Sci U S A. 2023. PMID: 37607224 Free PMC article.
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice.
Alhammad YM, Parthasarathy S, Ghimire R, O'Connor JJ, Kerr CM, Pfannenstiel JJ, Chanda D, Miller CA, Unckless RL, Zuniga S, Enjuanes L, More S, Channappanavar R, Fehr AR. Alhammad YM, et al. bioRxiv [Preprint]. 2023 Apr 6:2023.04.06.535927. doi: 10.1101/2023.04.06.535927. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2302083120. doi: 10.1073/pnas.2302083120 PMID: 37066301 Free PMC article. Updated. Preprint.
Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain.
Sherrill LM, Joya EE, Walker A, Roy A, Alhammad YM, Atobatele M, Wazir S, Abbas G, Keane P, Zhuo J, Leung AKL, Johnson DK, Lehtiö L, Fehr AR, Ferraris D. Sherrill LM, et al. Among authors: alhammad ym. Bioorg Med Chem. 2022 Aug 1;67:116788. doi: 10.1016/j.bmc.2022.116788. Epub 2022 May 11. Bioorg Med Chem. 2022. PMID: 35597097 Free PMC article.
Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV2 nsp3 Macrodomain.
Sherrill LM, Joya EE, Walker A, Roy A, Alhammad YM, Atobatele M, Wazir S, Abbas G, Keane P, Zhuo J, Leung AKL, Johnson DK, Lehtiö L, Fehr AR, Ferraris D. Sherrill LM, et al. Among authors: alhammad ym. bioRxiv [Preprint]. 2022 Feb 28:2022.02.27.482176. doi: 10.1101/2022.02.27.482176. bioRxiv. 2022. Update in: Bioorg Med Chem. 2022 Aug 1;67:116788. doi: 10.1016/j.bmc.2022.116788 PMID: 35262078 Free PMC article. Updated. Preprint.
Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening.
Roy A, Alhammad YM, McDonald P, Johnson DK, Zhuo J, Wazir S, Ferraris D, Lehtiö L, Leung AKL, Fehr AR. Roy A, et al. Among authors: alhammad ym. bioRxiv [Preprint]. 2022 Mar 2:2022.03.01.482536. doi: 10.1101/2022.03.01.482536. bioRxiv. 2022. Update in: Antiviral Res. 2022 Jul;203:105344. doi: 10.1016/j.antiviral.2022.105344 PMID: 35262075 Free PMC article. Updated. Preprint.
18 results