Lehtiö L - Search Results

1

Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV2 nsp3 Macrodomain.

Sherrill LM, Joya EE, Walker A, Roy A, Alhammad YM, Atobatele M, Wazir S, Abbas G, Keane P, Zhuo J, Leung AKL, Johnson DK, Lehtiö L, Fehr AR, Ferraris D. Sherrill LM, et al. Among authors: lehtio l. bioRxiv [Preprint]. 2022 Feb 28:2022.02.27.482176. doi: 10.1101/2022.02.27.482176. bioRxiv. 2022. Update in: Bioorg Med Chem. 2022 Aug 1;67:116788. doi: 10.1016/j.bmc.2022.116788 PMID: 35262078 Free PMC article. Updated. Preprint.

2

Activities and binding partners of E3 ubiquitin ligase DTX3L and its roles in cancer.

Vela-Rodríguez C, Lehtiö L. Vela-Rodríguez C, et al. Among authors: lehtio l. Biochem Soc Trans. 2022 Dec 16;50(6):1683-1692. doi: 10.1042/BST20220501. Biochem Soc Trans. 2022. PMID: 36421918 Review.

3

Structural basis of selective inhibition of human tankyrases.

Narwal M, Venkannagari H, Lehtiö L. Narwal M, et al. Among authors: lehtio l. J Med Chem. 2012 Feb 9;55(3):1360-7. doi: 10.1021/jm201510p. Epub 2012 Jan 25. J Med Chem. 2012. PMID: 22233320

4

Protein engineering approach to enhance activity assays of mono-ADP-ribosyltransferases through proximity.

Galera-Prat A, Alaviuhkola J, Alanen HI, Lehtiö L. Galera-Prat A, et al. Among authors: lehtio l. Protein Eng Des Sel. 2022 Feb 17;35:gzac006. doi: 10.1093/protein/gzac006. Protein Eng Des Sel. 2022. PMID: 36130221 Free PMC article.

5

An Evolutionary Perspective on the Origin, Conservation and Binding Partner Acquisition of Tankyrases.

Sowa ST, Bosetti C, Galera-Prat A, Johnson MS, Lehtiö L. Sowa ST, et al. Among authors: lehtio l. Biomolecules. 2022 Nov 15;12(11):1688. doi: 10.3390/biom12111688. Biomolecules. 2022. PMID: 36421702 Free PMC article.

6

Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim.

Herman MD, Nyman T, Welin M, Lehtiö L, Flodin S, Trésaugues L, Kotenyova T, Flores A, Nordlund P. Herman MD, et al. Among authors: lehtio l. FEBS Lett. 2008 Oct 29;582(25-26):3590-4. doi: 10.1016/j.febslet.2008.09.028. Epub 2008 Sep 21. FEBS Lett. 2008. PMID: 18812174 Free article.

7

Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage.

Venkannagari H, Verheugd P, Koivunen J, Haikarainen T, Obaji E, Ashok Y, Narwal M, Pihlajaniemi T, Lüscher B, Lehtiö L. Venkannagari H, et al. Among authors: lehtio l. Cell Chem Biol. 2016 Oct 20;23(10):1251-1260. doi: 10.1016/j.chembiol.2016.08.012. Epub 2016 Sep 22. Cell Chem Biol. 2016. PMID: 27667561 Free article.

8

Unusual twinning in an acetyl coenzyme A synthetase (ADP-forming) from Pyrococcus furiosus.

Lehtiö L, Fabrichniy I, Hansen T, Schönheit P, Goldman A. Lehtiö L, et al. Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):350-4. doi: 10.1107/S0907444904034389. Epub 2005 Feb 24. Acta Crystallogr D Biol Crystallogr. 2005. PMID: 15735347

9

Screening and structural analysis of flavones inhibiting tankyrases.

Narwal M, Haikarainen T, Fallarero A, Vuorela PM, Lehtiö L. Narwal M, et al. Among authors: lehtio l. J Med Chem. 2013 May 9;56(9):3507-17. doi: 10.1021/jm3018783. Epub 2013 Apr 24. J Med Chem. 2013. PMID: 23574272

10

Structure of Escherichia coli pyruvate formate-lyase with pyruvate.

Lehtiö L, Leppänen VM, Kozarich JW, Goldman A. Lehtiö L, et al. Acta Crystallogr D Biol Crystallogr. 2002 Dec;58(Pt 12):2209-12. doi: 10.1107/s0907444902016402. Epub 2002 Nov 23. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 12454503

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