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Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans.
Zhu Y, Prata LGPL, Gerdes EOW, Netto JME, Pirtskhalava T, Giorgadze N, Tripathi U, Inman CL, Johnson KO, Xue A, Palmer AK, Chen T, Schaefer K, Justice JN, Nambiar AM, Musi N, Kritchevsky SB, Chen J, Khosla S, Jurk D, Schafer MJ, Tchkonia T, Kirkland JL. Zhu Y, et al. Among authors: schaefer k. EBioMedicine. 2022 Mar;77:103912. doi: 10.1016/j.ebiom.2022.103912. Epub 2022 Mar 13. EBioMedicine. 2022. PMID: 35292270 Free PMC article.
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Zhu Y, Tchkonia T, Kirkland JL. Hickson LJ, et al. Among authors: schaefer kk. EBioMedicine. 2019 Sep;47:446-456. doi: 10.1016/j.ebiom.2019.08.069. Epub 2019 Sep 18. EBioMedicine. 2019. PMID: 31542391 Free PMC article.
Corrigendum to 'Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease' EBioMedicine 47 (2019) 446-456.
Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Allison DB, Dickinson SL, Ejima K, Atkinson EJ, Lenburg M, Zhu Y, Tchkonia T, Kirkland JL. Hickson LJ, et al. Among authors: schaefer kk. EBioMedicine. 2020 Feb;52:102595. doi: 10.1016/j.ebiom.2019.12.004. Epub 2020 Jan 23. EBioMedicine. 2020. PMID: 31982828 Free PMC article. No abstract available.
TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states.
Panzeri I, Fagnocchi L, Apostle S, Tompkins M, Wolfrum E, Madaj Z, Hostetter G, Liu Y, Schaefer K, Yang CH, Bergsma A, Drougard A, Dror E; PERMUTE; Chandler DP, Schramek D, Triche TJ Jr, Pospisilik JA. Panzeri I, et al. Among authors: schaefer k. Nat Cancer. 2025 Jan 24. doi: 10.1038/s43018-024-00900-3. Online ahead of print. Nat Cancer. 2025. PMID: 39856421
Life satisfaction around the world: Measurement invariance of the Satisfaction With Life Scale (SWLS) across 65 nations, 40 languages, gender identities, and age groups.
Swami V, Stieger S, Voracek M, Aavik T, Abdollahpour Ranjbar H, Adebayo SO, Afhami R, Ahmed O, Aimé A, Akel M, Al Halbusi H, Alexias G, Ali KF, Alp-Dal N, Alsalhani AB, Álvarez-Solas S, Amaral ACS, Andrianto S, Aspden T, Argyrides M, Aruta JJBR, Atkin S, Ayandele O, Baceviciene M, Bahbouh R, Ballesio A, Barron D, Bellard A, Bender SS, Beydaǧ KD, Birovljević G, Blackburn MÈ, Borja-Alvarez T, Borowiec J, Bozogáňová M, Bratland-Sanda S, Browning MHEM, Brytek-Matera A, Burakova M, Çakır-Koçak Y, Camacho P, Camilleri VE, Cazzato V, Cerea S, Chaiwutikornwanich A, Chaleeraktrakoon T, Chambers T, Chen QW, Chen X, Chien CL, Chobthamkit P, Choompunuch B, Compte EJ, Corrigan J, Cosmas G, Cowden RG, Czepczor-Bernat K, Czub M, da Silva WR, Dadfar M, Dalley SE, Dany L, Datu JAD, de Carvalho PHB, Coelho GLH, De Jesus AOS, Debbabi SH, Dhakal S, Di Bernardo F, Dimitrova DD, Dion J, Dixson B, Donofrio SM, Drysch M, Du H, Dzhambov AM, El-Jor C, Enea V, Eskin M, Farbod F, Farrugia L, Fian L, Fisher ML, Folwarczny M, Frederick DA, Fuller-Tyszkiewicz M, Furnham A, García AA, Geller S, Ghisi M, Ghorbani A, Gomez Martinez MA, Gradidge S, Graf S, Grano C, Gyene G, Hallit S, Hamdan M, Handelzalts JE, Hanel… See abstract for full author list ➔ Swami V, et al. Among authors: schaefer k. PLoS One. 2025 Jan 22;20(1):e0313107. doi: 10.1371/journal.pone.0313107. eCollection 2025. PLoS One. 2025. PMID: 39841629 Free PMC article.
Evaluating sources of mercury in Canada's Mackenzie River.
Jermilova U, Kirk JL, Dastoor A, Schaefer K, Hintelmann HH. Jermilova U, et al. Among authors: schaefer k. Sci Total Environ. 2025 Jan 16;963:178458. doi: 10.1016/j.scitotenv.2025.178458. Online ahead of print. Sci Total Environ. 2025. PMID: 39824099 Free article. Review.
767 results